Immunomodulatory vitamin D effects on regulatory T-cells and cytokines in an in vitro study on patients with systemic lupus erythematosus

Ghoryani, M. and Sahebari, M. and Mahmoudi, M. and Abdollahi, N. and Reihani, H. and Rabe, S. Z. T. and Tabasi, N. and Rastin, M. (2016) Immunomodulatory vitamin D effects on regulatory T-cells and cytokines in an in vitro study on patients with systemic lupus erythematosus. Food and Agricultural Immunology, 27 (3). pp. 377-387.

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Abstract

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease affecting various organs. Decreased numbers of regulatory T-cells (Treg cells; CD4+CD25highFoxp3+) are associated with the pathogenesis of SLE. A vitamin D deficiency was observed in many lupus patients. In the present study, peripheral blood mononuclear cells were isolated and cultured in the presence or absence of vitamin D, and total Tregs percentage was analyzed by flow cytometry. In addition, the level of expressions of Foxp3, TGFβ, and IL6 genes were analyzed by real-time-PCR. The results indicated that vitamin D treatment increased the percentage of Treg cells, and the expression of Foxp3 and TGFβ, and decreased the expression of IL6 in SLE patients. © 2015 Taylor & Francis.

Item Type: Article
Additional Information: Cited By :7 Export Date: 16 February 2020 CODEN: FAIME Correspondence Address: Rastin, M.; Immunology Research Center, BuAli Research Institute, Mashhad University of Medical SciencesIran; email: rastinm@mums.ac.ir
Uncontrolled Keywords: Foxp3 IL10 IL6 regulatory T-cells Systemic lupus erythematosus TGFB Vitamin D
Subjects: QW Microbiology and Immunology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib4 lib4
Date Deposited: 02 Mar 2020 07:52
Last Modified: 02 Mar 2020 07:52
URI: http://eprints.mums.ac.ir/id/eprint/13010

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