Antibiotic resistance properties of uropathogenic Escherichia coli isolated from pregnant women with history of recurrent urinary tract infections

Habibi, A. and Khameneie, M. K. (2016) Antibiotic resistance properties of uropathogenic Escherichia coli isolated from pregnant women with history of recurrent urinary tract infections. Tropical Journal of Pharmaceutical Research, 15 (8). pp. 1745-1750.

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Abstract

Purpose: To investigate the antibiotic resistance pattern of uropathogenic Escherichia coli (UPEC) strains isolated from pregnant women with history of recurrent urinary tract infections (RUTIs) and healthy pregnant women. Methods: A total of 485 high vaginal swab specimens were collected from pregnant women with history of RUTIs and healthy ones. Samples were cultured and those that were E. coli positive were analyzed by polymerase chain reaction (PCR) and disk diffusion tests. Results: Twenty eight out of 445 (6.29 ) samples were positive for E. coli. Prevalence of E. coli in pregnant women with history of RUTIs and healthy ones were 9 and 4.08 , respectively. Women older than 40 years were the most commonly infected. UPEC strains showed the highest levels of resistance against ampicillin (96.42 ), tetracycline (85.71 ), amikacin (71.42 ), ciprofloxacin (67.85 ) and gentamycin (58.71 ). Conclusion: RUTIs and pregnancy in old age are two important risk factors for transmission of UPEC strains from the urinary tract into the vagina. Primary treatment of infected pregnant women with imipenem, mezlocillin and nitrofurantoin would be effective for the prevention and management of vaginal infections in pregnant women. © Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, 300001 Nigeria.

Item Type: Article
Additional Information: Cited By :3 Export Date: 16 February 2020 Correspondence Address: Khameneie, M.K.; Department of Gynecology, Imam Reza Hospital, AJA University of Medical SciencesIran; email: dr.khameneie@yahoo.com
Uncontrolled Keywords: Antibiotic resistance Pregnant women Recurrent urinary tract infections Uropathogenic escherichia coli amikacin ampicillin cefalotin cefotaxime ciprofloxacin clindamycin cotrimoxazole gentamicin imipenem mezlocillin nalidixic acid nitrofurantoin norfloxacin ofloxacin tetracycline adult Article bacterium identification controlled study disk diffusion female human major clinical study polymerase chain reaction pregnant woman prevalence recurrent infection urinary tract infection vagina smear vaginitis young adult
Subjects: WJ Urogenital System
WP Gynecology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib4 lib4
Date Deposited: 02 Mar 2020 08:08
Last Modified: 02 Mar 2020 08:08
URI: http://eprints.mums.ac.ir/id/eprint/13013

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