Pentacam top indices for diagnosing subclinical and definite keratoconus

Hashemi, H. and Beiranvand, A. and Yekta, A. and Maleki, A. and Yazdani, N. and Khabazkhoob, M. (2016) Pentacam top indices for diagnosing subclinical and definite keratoconus. Journal of Current Ophthalmology, 28 (1). pp. 21-26.

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Abstract

Purpose: To determine pachymetric, aberrometric, and topometric indices in patients with definite and subclinical keratoconus and the validity of these indices in the diagnosis of keratoconus. Methods: We evaluated 262 keratoconic and 97 healthy eyes in this study. Pentacam HR examination was performed for all participants, and the data of all pachymetric, aberrometric, and topometric indices was extracted for the study population. Results: The average of all evaluated pachymetric and topometric indices and the 3rd and 5th order vertical coma aberrations showed a significant difference between the study groups (p < 0.001). Belin/Ambrosio Deviation Display (BADD), Index of Vertical Asymmetry (IVA), Index of Surface Variance (ISV), and 5th order vertical coma aberration were identified as the best diagnostic criteria for the diagnosis of subclinical keratoconus (R2 = 0.65, p <0.001), and BADD, mean keratometry and 3rd order vertical coma aberration were identified as the best diagnostic criteria for the diagnosis of definite keratoconus (R2 = 0.91, p <0.001). The sensitivity and specificity of the above-mentioned models were 83.6 and 96.9, and 97.9 and 96.9, respectively. Conclusion: Simultaneous evaluation of BADD, 5th order vertical coma aberration, IVA, and ISV, especially when the pattern of the corneal curvature is normal, can detect subclinical keratoconus with high sensitivity and specificity. As for definite keratoconus, each of the BADD, mean keratometry, and 3rd order vertical coma aberration indices has a desirable diagnostic validity. However, the aforementioned indices do not negate the importance of widely recognized and acceptable indices like keratometry and central corneal thickness. © 2016 Iranian Society of Ophthalmology.

Item Type: Article
Additional Information: Cited By :23 Export Date: 16 February 2020 Correspondence Address: Beiranvand, A.; Health and nutrition Research Center, Lorestan University of Medical SciencesIran; email: beiranvand83@yahoo.com
Uncontrolled Keywords: aberrometry adult Article clinical examination controlled study cornea thickness corneal pachymetry diagnostic imaging diagnostic test accuracy study diagnostic value disease severity eye examination female human keratoconus keratometry major clinical study male ophthalmic camera receiver operating characteristic sensitivity and specificity
Subjects: WA Public Health
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib4 lib4
Date Deposited: 02 Mar 2020 06:31
Last Modified: 02 Mar 2020 06:31
URI: http://eprints.mums.ac.ir/id/eprint/13023

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