Lymphatic mapping and sentinel node biopsy in ovarian tumors: A study using intra-operative Tc-99m-Phytate and lymphoscintigraphy imaging

Hassanzadeh, M. and Hosseini Farahabadi, E. and Yousefi, Z. and Kadkhodayan, S. and Zarifmahmoudi, L. and Sadeghi, R. (2016) Lymphatic mapping and sentinel node biopsy in ovarian tumors: A study using intra-operative Tc-99m-Phytate and lymphoscintigraphy imaging. Journal of Ovarian Research, 9 (1).

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Abstract

Background: Experience on sentinel node mapping in ovarian tumors is very limited. We evaluated the sentinel node concept in ovarian tumors using intra-operativeTc-99m-Phytate injection and lymphoscintigraphy imaging. Methods: Thirty-five patients with a pelvic mass due to an ovarian pathology were included in the study. The radiotracer was injected just after laparotomy and before removal of the tumor either beneath the normal cortex (10 patients) or in the utero-ovarian and suspensory ligaments of the ovary just beneath the peritoneum two injections of the radiotracer (25 patients). For malignant masses, the sentinel nodes were identified using a hand held gamma probe. Then standard pelvic and para-aortic lymphadenectomy was performed. In case of benign pathologies or borderline ovarian tumors on frozen section, lymphadenectomy was not performed. The morning after surgery, all patients were sent for lymphoscintigraphy imaging of the abdomen and pelvis. Results: Sentinel node was identified only in 4 patients of the cortical injection group. At least one sentinel node could be identified in 21 patients of the sub-peritoneal group. Sentinel nodes were identified only in the para-aortic area in 21, pelvic/para-aortic areas in 2, and pelvic only area in 2 patients. Three patients had lymph node involvement and all had involved sentinel nodes (no false negative case). Conclusion: Sentinel node mapping using intra-operative injection of the radiotracer (in the utero-ovarian and suspensory ligaments of the ovary just beneath the peritoneum) is feasible in ovarian tumors. Technical aspects of this method should be explored in larger multicenter studies in the future. © 2016 The Author(s).

Item Type: Article
Additional Information: Cited By :9 Export Date: 16 February 2020 Correspondence Address: Sadeghi, R.; Nuclear Medicine Research Center, Mashhad University of Medical SciencesIran; email: sadeghir@mums.ac.ir
Uncontrolled Keywords: Blue dye Lymphatic mapping Lymphoscintigraphy Ovarian tumor Ovary Sentinel phytate tc 99m tracer phytic acid technetium complex technetium phytate abdomen abdominal hysterectomy Article clinical article female frozen section human human tissue laparotomy lymph node dissection medical procedures ovary tumor pelvis priority journal salpingooophorectomy sentinel lymph node biopsy sentinel node mapping adolescent adult aged diagnostic imaging intraoperative monitoring lymph node lymph node metastasis middle aged Ovarian Neoplasms pathology procedures Humans Lymph Node Excision Lymph Nodes Lymphatic Metastasis Monitoring, Intraoperative Organotechnetium Compounds
Subjects: WN Radiology . Diagnostic Imaging
QZ pathology-neoplasms-Genetics
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib4 lib4
Date Deposited: 02 Mar 2020 07:15
Last Modified: 02 Mar 2020 07:15
URI: http://eprints.mums.ac.ir/id/eprint/13029

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