Prooxidant-Antioxidant Balance in Patients with Systemic Lupus Erythematosus and Its Relationship with Clinical and Laboratory Findings

Jafari, S. M. and Salimi, S. and Nakhaee, A. and Kalani, H. and Tavallaie, S. and Farajian-Mashhadi, F. and Zakeri, Z. and Sandoughi, M. (2016) Prooxidant-Antioxidant Balance in Patients with Systemic Lupus Erythematosus and Its Relationship with Clinical and Laboratory Findings. Autoimmune Diseases, 2016.

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Abstract

Aim. This study was aimed at evaluating prooxidant-antioxidant balance (PAB) in patients with systemic lupus erythematosus (SLE) and its relationship with laboratory findings and clinical manifestations. Methods. In this case-control study, 60 patients with SLE and 60 healthy individuals were enrolled. The blood samples were collected and their sera were separated. Subsequently, the prooxidant-antioxidant balance value was evaluated using PAB assay for each sample. Results. The mean of PAB values in SLE patients was significantly higher than healthy controls (147.3 ± 42 versus 84.8 ± 32.2 HK, P < 0.0001). Furthermore, in SLE patients, there was a positive significant correlation between the PAB and erythrocyte sedimentation rate (ESR) (r = 0.492, P < 0.001). In addition, the PAB values in patients with alopecia, discoid rash, oral ulcers, arthritis, and nephritis were significantly higher than those without these manifestations. Conclusion. The findings of current study showed that the mean of PAB was significantly higher in SLE patients and PAB was correlated with ESR. Moreover increased PAB was found in SLE patients with alopecia, discoid rash, oral ulcers, arthritis, and nephritis. These findings suggest that the measurement of PAB may be useful to show oxidative stress condition in SLE patients. Copyright © 2016 Seyyed Mehdi Jafari et al.

Item Type: Article
Additional Information: Cited By :1 Export Date: 16 February 2020 Correspondence Address: Salimi, S.; Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical SciencesIran; email: sasalimi@yahoo.com
Uncontrolled Keywords: hemoglobin adult alopecia antioxidant assay arthritis Article blood analysis case control study controlled study erythrocyte count erythrocyte sedimentation rate female hematocrit hemoglobin blood level homeostasis human inflammation laboratory test leukocyte count major clinical study male mouth ulcer nephritis neurologic disease photosensitivity priority journal prooxidant antioxidant balance rash systemic lupus erythematosus thrombocyte count
Subjects: QT physiology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib4 lib4
Date Deposited: 02 Mar 2020 05:04
Last Modified: 02 Mar 2020 05:04
URI: http://eprints.mums.ac.ir/id/eprint/13050

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