HER-2/neu overxpression in esophageal squamous cell carcinoma (ESCC) and its correlation with patient’s clinicopathological features

Kermani, A. T. and Vakili, R. and Dadkhah, S. and Jafarian, A. H. and Bagheri, R. (2016) HER-2/neu overxpression in esophageal squamous cell carcinoma (ESCC) and its correlation with patient’s clinicopathological features. International Journal of Cancer Management, 9 (5).

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Abstract

Background: HER-2/neu overexpression has been reported in various human cancers and identified as a significant predictor of poor survival. In this study HER-2/neu overexpression and its associations with clinicopathological characteristics were evaluated in patients with esophageal squamous cell carcinoma (ESCC). Methods: This cross-sectional study was performed on 64 patients with histological diagnosis of primary ESCC who underwent surgery for curative treatment. Immunohistochemistry (IHC) was used to assess expression of HER-2/neu receptor in formalin-fixed paraffin-embedded tissue blocks. Results: The mean age of patients was 60.1 ± 1.28 years. The overall HER2 expression was observed in 51.5 of ESCC patients without considering IHC scores. HER2/neu overexpression (6) was significantly associated with the tumor differentiation (P < 0.001). 20.3 of cases were stage I, 67.2 stage II, and 12.5 stage III. 17 patients (26.2) had vascular invasion, 12 patients (18.8) had neuronal invasion and 7 patients (10.9) had invasion to margins. Nine of 12 patients with HER-2/neu over expression had thoracic tumors and only three of them had an abdominal ESCC. Conclusions: No significant correlations were found between HER2/neu overexpression and gender, age, tumor invasion, location of tumor, TNM stages and stage of tumor in patients with ESCC. © 2016, Iranian Journal of Cancer Prevention.

Item Type: Article
Additional Information: Export Date: 16 February 2020 Correspondence Address: Bagheri, R.; Cardio-Thoracic Surgery and Transplant Research Center, Emam Reza Hospital Faculty of Medicine, Mashhad University of Medical SciencesIran; email: bagherir@mums.ac.ir
Uncontrolled Keywords: Differentiation ESCC HER-2/neu Overexpression adult aged Article cancer staging cancer surgery clinical feature controlled study cross-sectional study esophageal squamous cell carcinoma female gene expression gene overexpression human immunohistochemistry major clinical study male oncogene neu tumor differentiation tumor invasion
Subjects: WI Digestive System
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib4 lib4
Date Deposited: 02 Mar 2020 04:07
Last Modified: 02 Mar 2020 04:07
URI: http://eprints.mums.ac.ir/id/eprint/13060

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