Tissue composition effect on dose distribution in neutron brachytherapy/neutron capture therapy

Khosroabadi, M. and Farhood, B. and Ghorbani, M. and Hamzian, N. and Moghaddam, H. R. and Davenport, D. (2016) Tissue composition effect on dose distribution in neutron brachytherapy/neutron capture therapy. Reports of Practical Oncology and Radiotherapy, 21 (1). pp. 8-16.

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Abstract

Aim: The aim of this study is to assess the effect of the compositions of various soft tissues and tissue-equivalent materials on dose distribution in neutron brachytherapy/neutron capture therapy. Background: Neutron brachytherapy and neutron capture therapy are two common radiotherapy modalities. Materials and methods: Dose distributions were calculated around a low dose rate 252Cf source located in a spherical phantom with radius of 20.0cm using the MCNPX code for seven soft tissues and three tissue-equivalent materials. Relative total dose rate, relative neutron dose rate, total dose rate, and neutron dose rate were calculated for each material. These values were determined at various radial distances ranging from 0.3 to 15.0cm from the source. Results: Among the soft tissues and tissue-equivalent materials studied, adipose tissue and plexiglass demonstrated the greatest differences for total dose rate compared to 9-component soft tissue. The difference in dose rate with respect to 9-component soft tissue varied with compositions of the materials and the radial distance from the source. Furthermore, the total dose rate in water was different from that in 9-component soft tissue. Conclusion: Taking the same composition for various soft tissues and tissue-equivalent media can lead to error in treatment planning in neutron brachytherapy/neutron capture therapy. Since the International Commission on Radiation Units and Measurements (ICRU) recommends that the total dosimetric uncertainty in dose delivery in radiotherapy should be within ±5, the compositions of various soft tissues and tissue-equivalent materials should be considered in dose calculation and treatment planning in neutron brachytherapy/neutron capture therapy. © 2015 Greater Poland Cancer Centre. Published by Elsevier Sp. z o.o.

Item Type: Article
Additional Information: Cited By :10 Export Date: 16 February 2020 CODEN: RPORA Correspondence Address: Ghorbani, M.; Medical Physics Research Center, Mashhad University of Medical Sciences, Pardis-e-Daneshgah, Vakil Abad Blvd., Iran; email: mhdghorbani@gmail.com
Uncontrolled Keywords: 252Cf Dose rate Neutron brachytherapy Neutron capture therapy Tissue composition californium 252 poly(methyl methacrylate) water adipose tissue Article blood brachytherapy brain muscle neutron dosimetry radiation dose distribution radiology phantom soft tissue
Subjects: WN Radiology . Diagnostic Imaging
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib4 lib4
Date Deposited: 02 Mar 2020 04:31
Last Modified: 02 Mar 2020 04:31
URI: http://eprints.mums.ac.ir/id/eprint/13066

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