Immunotoxicity induced in mice by subacute exposure to berberine

Mahmoudi, M. and Zamani Taghizadeh Rabe, S. and Balali-Mood, M. and Karimi, G. and Memar, B. and Rahnama, M. and Tabasi, N. and Khazaee, M. and Riahi-Zanjani, B. (2016) Immunotoxicity induced in mice by subacute exposure to berberine. Journal of Immunotoxicology, 13 (2). pp. 255-262.

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The immunotoxic effects of the isoquinoline alkaloid berberine (BBR) were investigated in Balb/c mice. Here, BBR was administered daily by intraperitoneal injection at doses of 5 and 10 mg/kg for 14 days. Following the exposure, host spleen weight, cellularity and histopathology, as well as delayed-type hypersensitivity (DTH) responses, hemagglutination titers (HA), spleen cell subtype profiles, splenocyte cytokine production and lymphocyte proliferation were studied in all of the test groups of animals. The results showed that the high dose of BBR (10 mg/kg) could suppress both cellular and humoral immune functions in the treated hosts. BBR at 5 mg/kg only appeared to impact on DTH responses and lymphoproliferation. Based on the finding here, it would seem that BBR has effective immunosuppressive properties. Mechanistic studies are required to determine exactly how this material is acting to impart many of the immunotoxic effects demonstrated here. At the same time, further research should also be performed on BBR to further develop its potential use as an effective immunosuppressant or co-adjuvant for the treatment of diseases caused by an exaggerated or unwanted immune response. © 2015 Informa UK Limited trading as Taylor & Francis Group.

Item Type: Article
Additional Information: Cited By :13 Export Date: 16 February 2020 Correspondence Address: Riahi-Zanjani, B.; Medical Toxicology Research Center, School of Medicine, Mashhad University of Medical SciencesIran; email:
Uncontrolled Keywords: Berberine cellular immunity humoral immunity immunotoxicity cyclophosphamide animal cell animal experiment antibody titer Article cell stimulation controlled study delayed hypersensitivity drug effect drug exposure drug mechanism drug megadose hemagglutination histopathology immunomodulation lymphocyte proliferation male mouse nonhuman priority journal spleen cell spleen weight animal Bagg albino mouse cell proliferation chemically induced dose response drug effects immunology pathology spleen Animals Dose-Response Relationship, Drug Hypersensitivity, Delayed Immunity, Humoral Mice Mice, Inbred BALB C
Subjects: QW Microbiology and Immunology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib4 lib4
Date Deposited: 01 Mar 2020 10:15
Last Modified: 01 Mar 2020 10:15

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