Association of heat shock protein70-2 (HSP70-2) gene polymorphism with obesity

Mardan-Nik, M. and Pasdar, A. and Jamialahmadi, K. and Avan, A. and Mohebati, M. and Esmaily, H. and Biabangard-Zak, A. and Afzal Javan, F. and Rivandi, M. and Ferns, G. A. and Ghayour-Mobarhan, M. (2016) Association of heat shock protein70-2 (HSP70-2) gene polymorphism with obesity. Annals of Human Biology, 43 (6). pp. 542-546.

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Abstract

Background: Obesity is a major risk factor of chronic-diseases, including cardiovascular-diseases (CVD). Increasing evidence is showing the association of heat-shock protein (HSP) with type-2 diabetes and CVD; however, there is little data on the relationship between the genetic-polymorphisms of HSP70-2 with obesity. Aim: The present study has investigated the association between 1267HSP70-2 genetic polymorphism and obesity in an Iranian population with 317 subjects. Subjects and methods: Anthropometric parameters and biochemical measurements were measured in all the samples, while genotypes were determined using PCR-RFLP. Univariate/multivariate analyses were conducted to explore the relationship between the genetic-polymorphisms and obesity. Results: The data showed a significant association between 1267HSP70-2 polymorphism in obese subjects, compared to the non-obese group. Moreover, it was observed that this polymorphism was associated with obesity in the CAD + group, which had a high BMI compared to non-obese controls. Conclusion: The 1267HSP70-2 polymorphism is associated with obesity in an Iranian population, supporting a possible potential genetic link between obesity and cardiovascular diseases. © 2016 Informa UK Limited, trading as Taylor & Francis Group.

Item Type: Article
Additional Information: Cited By :11 Export Date: 16 February 2020 CODEN: AHUBB Correspondence Address: Ghayour-Mobarhan, M.; Biochemistry of Nutrition Research Center, Faculty of Medicine, Mashhad University of Medical ScienceIran; email: ghayourm@mums.ac.ir
Uncontrolled Keywords: coronary artery disease heat shock protein 70 Obesity PCR-RFLP polymorphism cardiovascular disease cohort analysis diabetes health risk heat shock polymerization protein Iran HSPA1B protein, human adult aged allele biological model case control study demography female gene frequency genetic association study genetic predisposition genetics human male middle aged polymerase chain reaction restriction fragment length polymorphism single nucleotide polymorphism Alleles Case-Control Studies Genetic Association Studies Genetic Predisposition to Disease HSP70 Heat-Shock Proteins Humans Models, Genetic Polymorphism, Restriction Fragment Length Polymorphism, Single Nucleotide
Subjects: QU Biochemistry
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib4 lib4
Date Deposited: 01 Mar 2020 10:21
Last Modified: 01 Mar 2020 10:21
URI: http://eprints.mums.ac.ir/id/eprint/13079

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