The effect of ginger supplementation on serum C-reactive protein, lipid profile and glycaemia: A systematic review and meta-analysis

Mazidi, M. and Gao, H. K. and Rezaie, P. and Ferns, G. A. (2016) The effect of ginger supplementation on serum C-reactive protein, lipid profile and glycaemia: A systematic review and meta-analysis. Food and Nutrition Research, 60 (1).

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Aim: To undertake a systematic review and meta-analysis of prospective studies to determine the effect of ginger supplementation on serum C-reactive protein (CRP), lipid profile, and glycaemia. Method: PubMed-MEDLINE, Web of Science, Cochrane Database, and Google Scholar databases were searched (up until July 2016) to identify prospective studies evaluating the impact of ginger supplementation on serum CRP. Random-effects model meta-analysis was used for quantitative data synthesis. Sensitivity analysis was conducted using the leave-one-out method. Heterogeneity was quantitatively assessed using the I2 index. Systematic review registration: CRD42016035973. Results: From a total of 265 entries identified via searches, 9 studies were included in the final selection. The meta-analysis indicated a significant reduction in serum CRP concentrations following ginger supplementation weighted mean difference (WMD) - 0.84 mg/L (95% CI - 1.38 to - 0.31, I2 56.3%). The WMD for fasting blood glucose and HbA1c was - 1.35mg/dl(95%CI - 2.04 to - 0.58, I2 12.1%) and - 1.01 (95% CI - 1.28 to - 0.72, I2 9.4%), respectively. Moreover, high-density lipoprotein and triglyceride significantly improved after ginger administration 1.16 mg/dl (95% CI 0.52 to 1.08, I2 12.3%) and - 1.63 mg/dl (95% CI - 3.10 to - 0.17, I2 8.1%), respectively. These findings were robust in sensitivity analyses. Random-effects meta-regression revealed that changes in serum CRP levels were independent of the dosage of ginger supplementation (slope - 0.20; 95% CI - 0.95 to 0.55;p =0.60). Conclusions: This meta-analysis suggests that ginger supplementation significantly reduces serum CRP and improves glycaemia indexes and lipid profile. Randomized control trials with larger sample size and with a longer-term follow-up period should be considered for future investigations.

Item Type: Article
Additional Information: Cited By :18 Export Date: 16 February 2020 Correspondence Address: Gao, H.-K.; Department of General Surgery, General Hospital of Chinese People's Armed Police ForcesChina; email:
Uncontrolled Keywords: C-reactive protein Fasting blood glucose Ginger Lipids Meta-analysis Supplementation C reactive protein glucose hemoglobin A1c high density lipoprotein lipid low density lipoprotein triacylglycerol body mass cholesterol blood level continuous ambulatory peritoneal dialysis controlled clinical trial (topic) glucose blood level human hyperlipidemia meta analysis non insulin dependent diabetes mellitus obesity peritoneal dialysis randomized controlled trial (topic) Review systematic review
Subjects: QU Biochemistry
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib4 lib4
Date Deposited: 01 Mar 2020 11:04
Last Modified: 01 Mar 2020 11:04

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