The impact of vitamin D supplement intake on vascular endothelial function; a systematic review and meta-analysis of randomized controlled trials

Mazidi, M. and Karimi, E. and Rezaie, P. and Vatanparast, H. (2016) The impact of vitamin D supplement intake on vascular endothelial function; a systematic review and meta-analysis of randomized controlled trials. Food and Nutrition Research, 61 (1).

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Abstract

Aim: to systematically review and conduct a meta-analysis of randomized controlled trials investigating the impact of vitamin D supplementation on endothelial function. Method: We searched PubMed-Medline, SCOPUS, Web of Science and Google Scholar (until June 2016) to detect prospective studies evaluating the impact of vitamin D supplementation on endothelial function indexes. We used random effects models (using DerSimonian-Laird method) and generic inverse variance methods to synthesize quantitative data. We used the leave-one-out method for sensitivity analysis. To quantitatively assess the heterogeneity we used the I2 index. Systematic review registration: CRD42016039329. Results: From a total of 213 entries identified, 12 studies were appropriate for inclusion into the final analysis. The meta-analysis indicated a significant enhancement in flow-mediated dilation (FMD) following D supplementation (vitamin D intervention group versus control group 1.27 , (95 CI 0.20 to 2.34, N = 11 arms, heterogeneity p = 0.054; I2 51.2 ). These findings were robust in sensitivity analyses. Conclusions: This meta-analysis suggested that vitamin D supplementation may improve endothelial function. Randomized control trials with a longer-term follow-up are warranted to clarify the existing controversies and shed light on the potential underlying mechanisms. © 2017 The Author(s).

Item Type: Article
Additional Information: Cited By :11 Export Date: 16 February 2020 Correspondence Address: Vatanparast, H.; Health Sciences E-Wing, 104 Clinic Place, Canada; email: vatan.h@usask.ca
Uncontrolled Keywords: Endothelial function Flow-mediated dilation Meta-analysis Vitamin D flow measurement human meta analysis nutritional health prospective study randomized controlled trial (topic) Review sensitivity analysis systematic review vascular endothelium vasodilatation vitamin intake
Subjects: WG Cardiovascular System
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib4 lib4
Date Deposited: 01 Mar 2020 11:06
Last Modified: 01 Mar 2020 11:06
URI: http://eprints.mums.ac.ir/id/eprint/13085

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