Impact of different types of tree nut, peanut, and soy nut consumption on serum C-reactive protein (CRP): A systematic review and meta-analysis of randomized controlled clinical trials

Mazidi, M. and Rezaie, P. and Ferns, G. A. and Gao, H. K. (2016) Impact of different types of tree nut, peanut, and soy nut consumption on serum C-reactive protein (CRP): A systematic review and meta-analysis of randomized controlled clinical trials. Medicine (United States), 95 (44).

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Abstract

Background: The effects of different types of tree nut, peanut, and soy nut consumption on serum C-reactive protein (CRP) are not well established. we aimed to undertake a systematic review and meta-analysis of prospective studies to determine the effect of nut consumption (tree nuts, peanuts, and soy nuts) on serum CRP. Method: PubMed-Medline, Web of Science, Cochrane Database, and Google Scholar databases were searched (up until April 20 2016) to identify prospective studies evaluating the impact of tree nut, peanut, and soy nut consumption on serum CRP. Random effects models meta-analysis was used for quantitative data synthesis. Sensitivity analysis was conducted using the leave-one-out method. Heterogeneity was quantitatively assessed using the I2 index. Systematic review registration: CRD42016038044. Results: From a total of 844 entries identified via searches, 20 studies were included in the final selection. The meta-analysis indicated a nonsignificant increase in serum CRP concentrations following nut consumption (weighted mean difference WMD 0.17 mg/L, (95% CI-0.67 to 0.33, I2 52.1%). The WMDs for IL6 was-0.06(ng/dL), (95% CI-0.69 to 0.56, I2 9.6%),-0.71(mg/dL), (95% CI-1.11 to-0.30, I2 6.3%), for leptin, and-0.60(mg/dL), (95% CI-1.88 to 0.68, I2 5.6%) for adiponectin, and0.18(mg/dL), (95% CI-1.24 to 0.88, I2 9.3%) for IL10 and-0.37 (pg/mL), (95% CI-0.90 to 0.16, I2 7.9%) for TNF-α. These findings were robust in sensitivity analyses. Conclusions: This meta-analysis suggests that nut consumption significantly decrease leptin while have no significant effect on CRP, IL6, adiponectin, IL10, and TNF-α. Copyright © 2016 the Author(s). Published by Wolters Kluwer Health, Inc. All rights reserved.

Item Type: Article
Additional Information: Cited By :26 Export Date: 16 February 2020 CODEN: MEDIA Correspondence Address: Gao, H.-K.; Department of General Surgery, General Hospital of Chinese People's Armed Police ForcesChina; email: moshen@genetics.ac.cn
Uncontrolled Keywords: C-reactive protein Meta-analysis Peanut Tree nut C reactive protein Arachis diet human meta analysis nut prospective study randomized controlled trial (topic) soybean Humans Nuts Prospective Studies Randomized Controlled Trials as Topic Soybeans
Subjects: QU Biochemistry
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib4 lib4
Date Deposited: 01 Mar 2020 11:08
Last Modified: 01 Mar 2020 11:08
URI: http://eprints.mums.ac.ir/id/eprint/13086

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