Boron neutron capture therapy: Moving toward targeted cancer therapy

Mirzaei, H. and Sahebkar, A. and Salehi, R. and Nahand, J. and Karimi, E. and Jaafari, M. and Mirzaei, H. (2016) Boron neutron capture therapy: Moving toward targeted cancer therapy. Journal of Cancer Research and Therapeutics, 12 (2). pp. 520-525.

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Abstract

Boron neutron capture therapy (BNCT) occurs when a stable isotope, boton-10, is irradiated with low-energy thermal neutrons to yield stripped down helium-4 nuclei and lithium-7 nuclei. It is a binary therapy in the treatment of cancer in which a cytotoxic event is triggered when an atom placed in a cancer cell. Here, we provide an overview on the application of BNCT in cancer therapy as well as current preclinical and clinical evidence on the efficacy of BNCT in the treatment of melanoma, brain tumors, head and neck cancer, and thyroid cancer. Several studies have shown that BNCT is effective in patients who had been treated with a full dose of conventional radiotherapy, because of its selectivity. In addition, BNCT is dependent on the normal/tumor tissue ratio of boron distribution. Increasing evidence has shown that BNCT can be combined with different drug delivery systems to enhance the delivery of boron to cancer cells. The flexibility of BNCT to be used in combination with different tumor-targeting approaches has made this strategy a promising option for cancer therapy. This review aims to provide a state-of-the-art overview of the recent advances in the use of BNCT for targeted therapy of cancer.

Item Type: Article
Additional Information: Cited By :41 Export Date: 16 February 2020 Correspondence Address: Mirzaei, H.; Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical SciencesIran; email: mirzaeih911h@mums.ac.ir
Uncontrolled Keywords: Boron neutron capture therapy cancer radiotherapy alpha fetoprotein antibody boron cetuximab folic acid immunoliposome iodinated poppyseed oil liposome monoclonal antibody polymer temozolomide drug carrier biocompatibility brain tumor cancer cell cancer patient clinical research DNA repair drug delivery system drug efficacy glioblastoma human liposomal delivery melanoma molecularly targeted therapy neoplasm neutron capture therapy nonhuman Review survival rate cancer grading cancer staging clinical trial (topic) metastasis Neoplasms procedures Clinical Trials as Topic Drug Carriers Drug Delivery Systems Humans Neoplasm Grading Neoplasm Metastasis Neoplasm Staging
Subjects: QZ pathology-neoplasms-Genetics
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib4 lib4
Date Deposited: 01 Mar 2020 09:42
Last Modified: 01 Mar 2020 09:42
URI: http://eprints.mums.ac.ir/id/eprint/13093

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