SiRNA and epigenetic aberrations in ovarian cancer

Mirzaei, H. and Yazdi, F. and Salehi, R. and Mirzaei, H. (2016) SiRNA and epigenetic aberrations in ovarian cancer. Journal of Cancer Research and Therapeutics, 12 (2). pp. 498-508.

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Abstract

Ovarian cancer has the most noteworthy lethal rate around gynecologic malignancies, and it is also considered as the fourth most frequent cancer in the woman in world. Two most critical barriers to treatment of ovarian malignancy are absence of early diagnostic markers and advancement of drug resistance after therapy, especially in advanced stages. Various epigenetic changes have been recognized in ovarian cancer. Recent progresses in our understanding of molecular pathogenesis of ovarian malignancy have dramatically provided potential new targets for molecularly targeted therapies. In very recent years, small interfering RNA (siRNA)-mediated gene silencing has been emerging as a novel treatment modality in preclinical studies in the light of its strong gene-specific silencing. Gene suppression mediated by RNA interference (RNAi) significantly suppressed gene expression at the messenger RNA (mRNA) and protein levels. SiRNAs have therapeutic potential for ovarian cancer through various mechanisms. In this review, we not only provide an overview of siRNA designing for epigenetic silencing of genes aberrantly expressed in ovarian cancer but also we will highlight that the epigenetically silenced genes offer new targets for therapeutic approaches based on re-expression of tumor suppressor genes via demethylating and deacetylating drugs.

Item Type: Article
Additional Information: Cited By :52 Export Date: 16 February 2020 Correspondence Address: Mirzaei, H.; Department of Immunology, School of Medicine, Tehran University of Medical SciencesIran; email: h-mirzaei@razi.tums.ac.ir
Uncontrolled Keywords: Epigenetics ovarian cancer small interfering RNA therapy BMI1 protein BRCA1 protein claudin 3 claudin 4 DNA histone histone deacetylase 1 histone deacetylase 2 histone deacetylase 3 microRNA somatomedin B synuclein cancer gene therapy cancer genetics chromatin assembly and disassembly DNA methylation female gene expression gene silencing histone modification human ovary cancer Review RNAi therapeutics tumor suppressor gene gene expression regulation genetic epigenesis genetics metabolism molecularly targeted therapy Ovarian Neoplasms RNA interference Epigenesis, Genetic Gene Expression Regulation, Neoplastic Histones Humans Molecular Targeted Therapy RNA, Small Interfering
Subjects: WP Gynecology
QZ pathology-neoplasms-Genetics
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib4 lib4
Date Deposited: 01 Mar 2020 09:47
Last Modified: 01 Mar 2020 09:47
URI: http://eprints.mums.ac.ir/id/eprint/13095

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