Effects of sodium selenite on formaldehyde induced renal toxicity in mice

Mohammadi, S. and Moghimian, M. and Torabzadeh, H. and Langari, M. and Nazeri, R. and Karimi, Z. and Sangari, E. and Jagarmi, N. and Zadeh, A. M. and Mohammadi, M. and Karimi, M. and Tavakkoli, K. and Delshad, A. and Mohammadzadeh, F. and Ghayour-Mobarhan, M. (2016) Effects of sodium selenite on formaldehyde induced renal toxicity in mice. Pharmaceutical Sciences, 22 (4). pp. 227-233.

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Abstract

Background: Formaldehyde is widely used for industrial applications. Renal injury is an adverse effect associated with formaldehyde. Few studies have explored the potential benefits of protective factors on formaldehyde induced renal toxicity. This study evaluated the dose dependent effects of sodium selenite on the biochemical and histopathological effects of formaldehyde on murine kidney. Methods: Forty eight adult Balb/c male mice were randomized into six groups: a control group, a formaldehyde group and experimental III-VI groups. Formaldehyde group was injected with 10 mg/kg formaldehyde and groups III-VI received intraperitoneally doses of 0.1, 0.2, 0.4, 0.8 mg/kg selenium. After two weeks, a stereological study was done in accordance with the principle of Cavalieri and serum concentrations of urea and creatinine were measured. Data were analyzed using ANOVA and SPSS software. Results: Glomerosclerosis, necrosis and vacuolization were observed in the convoluted tubules of animals treated with formaldehyde. The biochemical markers, volume and count of glomeruli in the group treated with formaldehyde was significantly difference compared to the control group (P<0.05). The volume of the glomeruli in the group treated with 0.2 and 0.4 mg selenium and urea level in the group treated with 0.4 and 0.1 mg/kg selenium was significantly difference compared to the control group (P <0.05). The count of glomeruli and creatinine level in the selenium group was significantly difference compared to the control group (P ≤ 0.0001). Conclusions: A dose of 0.2 mg/kg of sodium selenite caused partial protective effect on the renal tissue and function in exposed to formaldehyde. © 2016 The Authors.

Item Type: Article
Additional Information: Cited By :1 Export Date: 16 February 2020 Correspondence Address: Torabzadeh, H.; St. Research Committee, Faculty of Medicine, Gonabad University of Medical SciencesIran; email: haniyet2013@gmail.com
Uncontrolled Keywords: Formaldehyde Kidney Mouse Selenium creatinine sodium selenite urea adult animal experiment animal model animal tissue Article cell vacuole controlled study creatinine blood level drug effect drug mechanism drug screening kidney necrosis kidney parenchyma kidney tubule male nephrotoxicity nonhuman renal protection urea blood level
Subjects: WJ Urogenital System
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib4 lib4
Date Deposited: 01 Mar 2020 08:05
Last Modified: 01 Mar 2020 08:05
URI: http://eprints.mums.ac.ir/id/eprint/13103

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