Adult onset of xanthelasmoid mastocytosis: Report of a rare entity

Nabavi, N. and Nejad, M. and Feli, S. and Bakhshoodeh, B. and Layegh, P. (2016) Adult onset of xanthelasmoid mastocytosis: Report of a rare entity. Indian Journal of Dermatology, 61 (4). p. 468.

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Xanthelasmoid or pseudoxanthomatous mastocytosis is an extremely rare variant of diffuse cutaneous mastocytosis. Herein, we describe an adult male with cutaneous mastocytosis showing multiple widespread yellowish ovoid papules like eruptive xanthoma. A 60-year-old male visited our outpatient clinic with a 1-year history of generalized yellowish, ovoid, and skin color papular eruption located on the trunk, groin, extremities, with the modest pruritus. Vital signs were stable, and Darier's sign was negative. No other subjective and objective signs were detected during the examination. No abnormality was detected in his diagnostic laboratory tests. Skin biopsy was taken, and histopathologic examination revealed proliferation of mast cells with ovoid and spindle nuclei with distinct cytoplasm borders around the capillaries, which was compatible with mastocytosis. Antihistamine was prescribed for pruritus control which was successful, but eruptions were persistent, and even 1-year phototherapy was not useful. © 2016 Indian Journal of Dermatology | Published by Wolters Kluwer - Medknow.

Item Type: Article
Additional Information: Cited By :1 Export Date: 16 February 2020 Correspondence Address: Layegh, P.; Department of Dermatology, Cutaneous Leishmaniasis Research Center, Quaem Hospital, School of Medicine, Mashhad University of Medical SciencesIran; email:
Uncontrolled Keywords: Adult mastocytosis pseudoxanthomatous xanthelasmoid cetirizine fexofenadine Article case report cell proliferation disease duration evening dosage histopathology human human tissue inguinal region limb male mast cell middle aged morning dosage outpatient department papular rash papule phototherapy physical examination pruritus skin biopsy skin color skin examination treatment failure trunk xanthelasmoid mastocytosis
Subjects: QZ pathology-neoplasms-Genetics
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib4 lib4
Date Deposited: 01 Mar 2020 07:01
Last Modified: 01 Mar 2020 07:01

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