Fonsecaea nubica sp. nov, a new agent of human chromoblastomycosis revealed using molecular data

Najafzadeh, M. J. and Sun, J. and Vicente, V. and Xi, L. and Van Den Ende, A. H. G. G. and De Hoog, G. S. (2010) Fonsecaea nubica sp. nov, a new agent of human chromoblastomycosis revealed using molecular data. Medical Mycology, 48 (6). pp. 800-806.

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Abstract

A new species of Fonsecaea, Fonsecaea nubica, morphologically similar to F. pedrosoi and F. monophora, is described using multilocus molecular data including AFLP profiles, sequences of the ribosomal internal transcribed spacers (ITS), and partial sequences of the cell division cycle (cdc42), β-tubulin (tub1) and actin (act1) genes. A phylogenetic approach was used to evaluate species delimitation. Topologies of the trees were concordant. Fonsecaea strains could be classified into three major entities, i.e., one representing Fonsecaea pedrosoi isolates, another consisting of strains of F. monophora, and a third, unnamed group comprising isolates mostly recovered from cases of chromoblastomycosis in South America and China. F. nubica is part of this latter group. Based on strains analyzed thus far, we have found that the pathologies of these three Fonsecaea species are somewhat different in that F. pedrosoi and F. nubica are preponderantly associated with chromoblastomycosis, while F. monophora may also act as a systemic opportunist in cases involving brain infections. The latter species is also the most frequently recovered of the three from environmental samples. © 2010 ISHAM.

Item Type: Article
Additional Information: Cited By :61 Export Date: 16 February 2020 CODEN: MEMYF Correspondence Address: De Hoog, G. S.; Centraalbureau voor Schimmelcultures, Fungal Biodiversity Centre, PO Box 85167, NL-3508 AD Utrecht, Netherlands; email: de.hoog@cbs.knaw.nl
Uncontrolled Keywords: Chromoblastomycosis Fonsecaea Molecular phylogeny Taxonomy actin beta tubulin internal transcribed spacer protein Cdc42 amplified fragment length polymorphism article chromomycosis controlled study Fonsecaea nubica Fonsecaea pedrosoi fungal genetics fungal strain gene sequence nonhuman nucleotide sequence unindexed sequence Actins Amplified Fragment Length Polymorphism Analysis Ascomycota cdc42 GTP-Binding Protein Cluster Analysis DNA Fingerprinting DNA, Fungal DNA, Ribosomal Spacer Fungal Proteins Genotype Humans Molecular Sequence Data Netherlands Phylogeny Sequence Analysis, DNA Tubulin Fonsecaea monophora
Subjects: QU Biochemistry
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib4 lib4
Date Deposited: 01 Mar 2020 07:17
Last Modified: 01 Mar 2020 07:17
URI: http://eprints.mums.ac.ir/id/eprint/13122

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