Effects of supplementation with curcumin on serum adipokine concentrations: A randomized controlled trial

Panahi, Y. and Hosseini, M. S. and Khalili, N. and Naimi, E. and Soflaei, S. S. and Majeed, M. and Sahebkar, A. (2016) Effects of supplementation with curcumin on serum adipokine concentrations: A randomized controlled trial. Nutrition, 32 (10). pp. 1116-1122.

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Objective Previous experimental studies have suggested curcumin as a safe phytochemical that can improve insulin resistance through effects on adiponectin and leptin. This study aimed to investigate the effect of curcumin on circulating adiponectin and leptin concentrations in patients with metabolic syndrome. Methods In this pilot, randomized, double-blind, placebo-controlled trial, subjects who met the criteria of metabolic syndrome according to the National Cholesterol Education Program Adult Treatment Panel III criteria were randomly assigned to curcumin (n = 59; 1000 mg/d) or a placebo (n = 58) for 8 wk. Serum adiponectin and leptin concentrations were determined before and after intervention. The pooled effect size for the impact of curcumin supplementation on serum adiponectin and leptin levels was also estimated using random-effects metaanalysis. Results Eight-week supplementation with curcumin was associated with a significant increase in serum adiponectin levels (P < 0.001) and a reduction in serum leptin concentrations (P < 0.001). Serum leptin:adiponectin ratio was also improved by curcumin (P < 0.001). These beneficial effects of curcumin remained significant after adjustment for changes in serum lipids and glucose concentrations and baseline differences in body mass index and serum levels of glucose and glycated hemoglobin as potential confounders of treatment response. Metaanalysis suggested that curcumin supplementation can increase adiponectin levels by 76.78 (95 CI: 6.14–147.42; P = 0.0330), and reduce leptin by 26.49 (95 CI: −70.44 to 17.46), however this latter effect size did not reach statistical significance (P = 0.238). Conclusions Curcumin can improve serum levels of adiponectin and leptin in patients with metabolic syndrome. This trial was registered at the UMIN Clinical Trials Registry (http://www.umin.ac.jp/ctr/) under Trial No. UMIN000018339. © 2016 Elsevier Inc.

Item Type: Article
Additional Information: Cited By :39 Export Date: 16 February 2020 CODEN: NUTRE Correspondence Address: Sahebkar, A.; Biotechnology Research Center, Mashhad University of Medical SciencesIran; email: Sahebkara@mums.ac.ir
Uncontrolled Keywords: Adiponectin Curcumin Leptin Meta-analysis Metabolic syndrome adipocytokine glucose hemoglobin A1c lipid piperine placebo ADIPOQ protein, human glucose blood level adiponectin leptin ratio adult analytical parameters Article body mass constipation controlled study diarrhea double blind procedure down regulation drug bioavailability drug effect drug response drug tolerability evidence based practice female headache hemoglobin blood level hormone blood level hormone determination human lipid blood level major clinical study male meta analysis metabolic syndrome X parallel design pilot study post hoc analysis priority journal protein blood level randomized controlled trial randomized controlled trial (topic) rash supplementation treatment duration upregulation blood diet therapy dietary supplement insulin resistance metabolism middle aged Adipokines Blood Glucose Dietary Supplements Double-Blind Method Humans Lipids Pilot Projects
Subjects: QU Biochemistry
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib4 lib4
Date Deposited: 01 Mar 2020 05:09
Last Modified: 01 Mar 2020 05:09
URI: http://eprints.mums.ac.ir/id/eprint/13141

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