Expression of p53 breast cancer in Kurdish women in the west of Iran: A reverse correlation with lymph node metastasis

Payandeh, M. and Sadeghi, M. and Sadeghi, E. and Madani, S. H. (2016) Expression of p53 breast cancer in Kurdish women in the west of Iran: A reverse correlation with lymph node metastasis. Asian Pacific Journal of Cancer Prevention, 17 (3). pp. 1261-1264.

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Abstract

Background: In breast cancer (BC), it has been suggested that nuclear overexpression of p53 protein might be an indicator of poor prognosis. The aim of the current study was to evaluate the expression of p53 BC in Kurdish women from the West of Iran and its correlation with other clinicopathology figures. Materials and Methods: In the present retrospective study, 231 patients were investigated for estrogen receptor (ER) and progesterone receptor (PR) positivity, defined as ≥10 positive tumor cells with nuclear staining. A binary logistic regression model was selected using Akaike Information Criteria (AIC) in stepwise selection for determination of important factors. Results: ER, PR, the human epidermal growth factor receptor 2 (HER2) and p53 were positive in 58.4, 55.4, 59.7 and 45 of cases, respectively. Ki67 index was divided into two groups: 54.5 had Ki67<20 and 45.5 had Ki67 ≥20. Of 214 patients, 137(64) had lymph node metastasis and of 186 patients, 122(65.6) had vascular invasion. Binary logistic regression analysis showed that there was inverse significant correlation between lymph node metastasis (P=0.008, OR 0.120 and 95CI 0.025-0.574), ER status (P=0.006, OR 0.080, 95CI 0.014-0.477) and a direct correlation between HER2 (P=005, OR 3.047, 95CI 1.407-6.599) with the expression of p53. Conclusions: As in a number of studies, expression of p53 had a inverse correlation with lymph node metastasis and ER status and also a direct correlation with HER2 status. Also, p53-positivity is more likely in triple negative BC compared to other subtypes.

Item Type: Article
Additional Information: Cited By :9 Export Date: 16 February 2020 Correspondence Address: Sadeghi, M.; Student Research Committee, Imam Reza Hospital, Kermanshah University of Medical SciencesIran; email: Sadeghimbrc@yahoo.com
Uncontrolled Keywords: Breast cancer Kurdish ethnicity Lymph node metastasis P53 Receptor expression epidermal growth factor receptor 2 ERBB2 protein, human estrogen receptor progesterone receptor protein p53 TP53 protein, human tumor marker adult aged Breast Neoplasms cancer grading cancer staging enzyme immunoassay female follow up human Iran metabolism middle aged prognosis retrospective study secondary tumor invasion very elderly young adult Aged, 80 and over Biomarkers, Tumor Follow-Up Studies Humans Immunoenzyme Techniques Lymphatic Metastasis Neoplasm Grading Neoplasm Invasiveness Neoplasm Staging Receptor, ErbB-2 Receptors, Estrogen Receptors, Progesterone Retrospective Studies Tumor Suppressor Protein p53
Subjects: WP Gynecology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib4 lib4
Date Deposited: 01 Mar 2020 05:15
Last Modified: 01 Mar 2020 05:15
URI: http://eprints.mums.ac.ir/id/eprint/13143

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