Urinary albumin-To-creatinine ratio is associated with endothelial dysfunction in HIV-infected patients receiving antiretroviral therapy

Pirro, M. and Mannarino, M. R. and Francisci, D. and Schiaroli, E. and Bianconi, V. and Bagaglia, F. and Sahebkar, A. and Mannarino, E. and Baldelli, F. (2016) Urinary albumin-To-creatinine ratio is associated with endothelial dysfunction in HIV-infected patients receiving antiretroviral therapy. Scientific Reports, 6.

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Abstract

Endothelial dysfunction, a marker of cardiovascular (CV) risk, is common in human immunodeficiency virus (HIV)-infected patients. Microalbuminuria is frequent in HIV-infected patients, and is a predictor of renal impairment and CV risk. We investigated the association between microalbuminuria and endothelial dysfunction among HIV-infected patients receiving highly-Active antiretroviral therapy (HAART). Endothelial function, measured by brachial artery flow-mediated dilatation (bFMD), and urine albumin-To-creatinine ratio (UACR), were measured in 170 HAART-Treated HIV-infected adults. The relationship between UACR and bFMD was evaluated. The prevalence of increased UACR, defined by two cut-off levels (20 mg/g and 30 mg/g), was 29 and 17. UACR was significantly higher while bFMD was lower among patients with metabolic syndrome (MS). UACR was associated with bFMD (r = â '0.31; p < 0.001). This association was stronger in MS-patients (r = â '0.44; p = 0.003). UACR above 20 mg/g was associated with an increased risk (OR 2.37, 95 CI 1.15-4.89, p = 0.020) of severely impaired bFMD (bFMD ≤ 2.1). Patients with MS and increased UACR had the lowest bFMD compared with those with none or one of the two conditions. Microalbuminuria and endothelial dysfunction are positively associated in HIV-infected patients regardless of known confounders. The coexistence of microalbuminuria and MS amplifies their deleterious influence on endothelial function.

Item Type: Article
Additional Information: Cited By :5 Export Date: 16 February 2020 Correspondence Address: Pirro, M.; Unit of Internal Medicine, Department of Medicine, University of PerugiaItaly; email: matteo.pirro@unipg.it
Uncontrolled Keywords: creatinine adult albuminuria brachial artery clinical trial female highly active antiretroviral therapy human Human immunodeficiency virus 1 Human immunodeficiency virus infection male metabolism middle aged pathology pathophysiology urine vascular endothelium vasodilatation Antiretroviral Therapy, Highly Active Endothelium, Vascular HIV Infections HIV-1 Humans Vasodilation
Subjects: WJ Urogenital System
QU Biochemistry
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib4 lib4
Date Deposited: 01 Mar 2020 05:22
Last Modified: 01 Mar 2020 05:22
URI: http://eprints.mums.ac.ir/id/eprint/13144

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