Serum pro-oxidant-antioxidant balance, advanced oxidized protein products (AOPP) and protein carbonyl in patients with stroke

Pouya, V. T. and Hashemy, S. I. and Shoeibi, A. and Tirkani, A. N. and Tavallaie, S. and Avval, F. Z. and Soukhtanloo, M. and Mashkani, B. A. and Alamdari, D. H. (2016) Serum pro-oxidant-antioxidant balance, advanced oxidized protein products (AOPP) and protein carbonyl in patients with stroke. Razavi International Journal of Medicine, 4 (2).

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Abstract

Background: Stroke is the second cause of death and disability in the world, and oxidative stress which could be considered as a prognostic factor in patients for prevention, follow up and determination of stroke’s severity has a conceivable role in neural damage. Objectives: The aim of our study was to explain the association between oxidant/antioxidant imbalance as a prognostic factor in patients with stroke. Patients and Methods: Pro-oxidant-antioxidant balance (PAB), advanced oxidized protein products (AOPP) and protein carbonyl were measured in patients with ischemic stroke and hemorrhagic stroke as well as healthy group. Sera were collected from 18 ischemic and 23 hemorrhagic stroke patients, and 34 healthy volunteers. The PAB assay, routine biochemical parameters, lipid profile and total protein concentration were assessed in patients and healthy group. Results: The level of AOPP (P < 0.007), protein carbonyl (P < 0.001) and PAB (P < 0.01) were significantly higher in stroke patients than the healthy group. Conclusions: There are increased level of protein carbonyl, AOPP and PAB in patients with stroke. Measuring these factors may be beneficial as prognostic factors in treatment and follow up of the patients with both hemorrhagic and ischemic strokes. More investigations with more cases and longer follow up are needed to approve that these factors play an important role in prognosis of stroke. © 2016, Razavi Hospital.

Item Type: Article
Additional Information: Cited By :1 Export Date: 16 February 2020 Correspondence Address: Alamdari, D.H.; Department of Biochemistry, Biochemistry and Nutrition Research Center, Faculty of Medicine, Mashhad University of Medical SciencesIran; email: HamidiAD@mums.ac.ir
Uncontrolled Keywords: Biochemical parameters Hemorrhagic strokes Ischemic strokes Lipid profile Oxidative stress PAB assay Prognostic factor Protein carbonyl Total protein concentration advanced oxidation protein product biological marker cholesterol creatinine glucose high density lipoprotein cholesterol low density lipoprotein cholesterol oxidizing agent pro oxidant antioxidant triacylglycerol unclassified drug urea advanced oxidation protein product assay Article biochemical analysis blood sampling brain hemorrhage brain ischemia cerebrovascular accident clinical article computer assisted tomography controlled study human lipid analysis prognosis protein content stroke prognosis
Subjects: QU Biochemistry
QZ pathology-neoplasms-Genetics
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib4 lib4
Date Deposited: 01 Mar 2020 05:32
Last Modified: 01 Mar 2020 05:32
URI: http://eprints.mums.ac.ir/id/eprint/13146

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