Evaluation of non-viral surrogate markers as predictive indicators for monitoring progression of human immunodeficiency virus infection: An eight-year analysis in a regional center

Rafatpanah, H. and Essmailian, L. and Hedayati-Moghaddam, M. R. and Vakili, R. and Norouzi, M. and Sarvghad, M. R. and Hosseinpour, A. M. and Sharebiani, H. and Rezaee, S. A. R. (2016) Evaluation of non-viral surrogate markers as predictive indicators for monitoring progression of human immunodeficiency virus infection: An eight-year analysis in a regional center. Japanese Journal of Infectious Diseases, 69 (1). pp. 39-44.

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Abstract

Suitable methods for clinical monitoring of HIV-infected patients are crucial in resourcepoor settings. Demographic data, clinical staging, and laboratory findings for 112 asymptomatic subjects positive for HIV were assessed at the first admission and the last visit from 2002 to 2010. Cox regression analysis showed hemoglobin (Hb) (HR = 0.643, P = 0.021) to be a predictive indicator for disease progression, while CD4, CD8, and platelet counts showed low HRs, despite having significant probability values. Hb and total lymphocyte count (TLC) rapidly declined from stage II to III (10.9 and 29.6z, respectively). Reduced CD4 and platelet counts and Hb during stage I were associated with disease progression, and TLC was correlated with CD4 counts at the last follow-up (P < 0.001). However, WHO TLC cutoff of 1,200 cell/mm3 had 26.1z sensitivity and 98.6z specificity. ROC curve analysis suggested that a TLC cutoff of 1,800 cell/mm3 was more reliable in this region. Statistical analysis and data mining findings showed that Hb and TLC, and their rapid decline from stage II to III, in addition to reduced platelet count, could be valuable markers for a surrogate algorithm for monitoring of HIVinfected subjects and starting anti-viral therapy in the absence of sophisticated detection assays. © 2016, National Institute of Health. All rights reserved.

Item Type: Article
Additional Information: Cited By :1 Export Date: 16 February 2020 CODEN: JJIDF Correspondence Address: Rezaee, S.A.R.; Inflammation and Inflammatory Diseases Research Center, Mashhad University of Medical SciencesIran; email: rezaeer@mums.ac.ir
Uncontrolled Keywords: hemoglobin biological marker adolescent adult algorithm Article CD4 lymphocyte count CD8 lymphocyte count disease course disease marker flow cytometry follow up hematocrit human Human immunodeficiency virus infection leukocyte count lymphocyte count major clinical study patient monitoring predictive value prognosis receiver operating characteristic sensitivity and specificity thrombocyte count female HIV Infections male middle aged pathology young adult Biomarkers Disease Progression Hemoglobins Humans Platelet Count
Subjects: QW Microbiology and Immunology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib4 lib4
Date Deposited: 29 Feb 2020 10:27
Last Modified: 29 Feb 2020 10:27
URI: http://eprints.mums.ac.ir/id/eprint/13150

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