Effects of Crocin on brain oxidative damage and aversive memory in a 6-OHDA model of Parkinson’s disease

Rajaei, Z. and Hosseini, M. and Alaei, H. (2016) Effects of Crocin on brain oxidative damage and aversive memory in a 6-OHDA model of Parkinson’s disease. Arquivos de Neuro-Psiquiatria, 74 (9). pp. 723-729.

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Abstract

The purpose of the present study was to investigate the effect of crocin on brain oxidative damage and memory deficits in a 6-hydroxydopamine (6-OHDA) model of Parkinson’s disease. Male Wistar rats were subjected to unilateral injection of 6-OHDA (16 μg) into the medial forebrain bundle and treated with crocin (30 and 60 mg/kg) for six weeks. The rats were tested for memory performance at six weeks after 6-OHDA infusion, and then were killed for the estimation of biochemical parameters. The increase in thiobarbituric acid reactive substances (TBARS) and nitrite levels in the hippocampus were observed in the 6-OHDA lesioned rats, which was accompanied by memory deficits in a passive avoidance test at the end of week 6. Moreover, treatment with crocin decreased TBARS and nitrite levels in the hippocampus, and improved aversive memory. The present study conclusively demonstrated that crocin acts as an antioxidant and anti-inflammatory agent in the hippocampus of parkinsonian rats and could improve aversive memory through its properties. © 2016, Associacao Arquivos de Neuro-Psiquiatria. All rights reserved.

Item Type: Article
Additional Information: Cited By :14 Export Date: 16 February 2020 CODEN: ANPIA Correspondence Address: Rajaei, Z.; Department of Physiology, School of Medicine, Isfahan University of Medical SciencesIran; email: rajaeiz@med.mui.ac.ir
Uncontrolled Keywords: 6-hydroxydopamine Aversive memory Crocin Medial forebrain bundle Nitric oxide Oxidative stress glutathione peroxidase malonaldehyde oxidopamine thiobarbituric acid reactive substance antioxidant carotenoid nitrite thiol derivative amnesia animal experiment animal model animal tissue Article aversive behavior biochemical analysis comparative study controlled study hippocampus lipid peroxidation male nonhuman oxidation Parkinson disease passive avoidance test performance rat spectral sensitivity animal brain cortex disease model drug effects evaluation study memory Memory Disorders metabolism pathophysiology physiology randomization Wistar rat Animals Antioxidants Carotenoids Cerebral Cortex Disease Models, Animal Nitrites Random Allocation Rats, Wistar Sulfhydryl Compounds Thiobarbituric Acid Reactive Substances
Subjects: WM Psychiatry
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib4 lib4
Date Deposited: 29 Feb 2020 11:02
Last Modified: 29 Feb 2020 11:02
URI: http://eprints.mums.ac.ir/id/eprint/13155

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