Effect of intracoronary sodium nitroprusside before percutaneous coronary intervention on periprocedural myonecrosis: A prospective randomized study

Ramezani, J. and Tayyebi, M. and Eshraghi, A. and Yazdi, M. J. (2016) Effect of intracoronary sodium nitroprusside before percutaneous coronary intervention on periprocedural myonecrosis: A prospective randomized study. Biomedical and Pharmacology Journal, 9 (1). pp. 239-246.

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The aim of this study is to evaluate the effect of pre PCI administration of intracoronary nitroprusside on post procedural myonecrosis. Myonecrosis is a prognostically important complication of PCI. Nitric oxide is a potent vasodilator in the resistance arteriolar circulation, and plays a significant role in the control of coronary blood flow through the microcirculation. nitroprussideis a direct donor of nitric oxide. A total of 62 patients were randomized into the NTP (n= 31) or control (n= 31) group. Patients who were scheduled for non-urgent PCI in de novo native coronary arteries were eligible. All patients were pretreated with statin, aspirin and clopidogrel. Myonecrosis was measured by CK-MB elevation 24 h after PCI. The NTP group received intracoronary NTP befor PCI, whereas the control group did not. All patients in NPT group received NTP for prevention of myonecrosis at a dose of at least 50 μg given intrcoronary through guiding catheter. 22 patients received 50μg,7 patients received 100μg and 3patients received 150μg. The baseline CPK-MB concentration was 16±4.89 and 16.55±6.18 in the control and NTP groups, respectively (P=0.70). The mean increase of CPK-MB concentration 24h after PCI was 20±26.64 and 10.13±14.35 in the control and NTP groups, respectively (P=0.06). Mean systolic BP before injection of NTP was 144.58±21.51mmHg and after injection of NPT was 121±21.51mmHg. Bolus administration of NTP through the guiding catheter is associated with reduction in the occurrence of myonecrosis following non-urgent PCI in patients pretreated with dual antiplatelet agents and statins.

Item Type: Article
Additional Information: Export Date: 16 February 2020 Correspondence Address: Yazdi, M.J.; Department of Cardiology, Atherosclerosis Prevention Research Center, School of Medicine, Mashhad University of Medical SciencesIran; email: jalalyazdim@mums.ac.ir
Uncontrolled Keywords: Percutaneous Coronary Intervention Periprocedural Myonecrosis Sodium Nitroprusside acetylsalicylic acid clopidogrel creatine kinase MB hydroxymethylglutaryl coenzyme A reductase inhibitor nitroprusside sodium adult aged Article controlled study coronary artery drug effect female guiding catheter human major clinical study male muscle necrosis prospective study randomized controlled trial systolic blood pressure
Subjects: WG Cardiovascular System
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib4 lib4
Date Deposited: 29 Feb 2020 11:12
Last Modified: 29 Feb 2020 11:12
URI: http://eprints.mums.ac.ir/id/eprint/13158

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