Evaluation of MAGE-1 cancer-testis antigen expression in invasive breast cancer and its correlation with prognostic factors

Rastgoosalami, M. and Memar, B. and Aledavood, S. A. and Fanipakdel, A. (2016) Evaluation of MAGE-1 cancer-testis antigen expression in invasive breast cancer and its correlation with prognostic factors. International Journal of Cancer Management, 9 (4).

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Abstract

Background: Aberrant expression of cancer-testis antigens (CTA) in breast carcinoma tissue, and its natural expression in the testis, the tissue away from the immune system, makes them good candidates for cancer immunotherapy and vaccines designing. Objectives: The aim of this study was to assess the expression of a CTA (MAGE-1) in invasive breast cancer and its correlation with prognostic factors. Methods: Paraffin blocks of breast cancer tissues from 113 patients operated in 2011 - 2013 were stained for MAGE-1expression by immunohistochemistry (IHC). The associations of MAGE-1 expression with known prognostic factors were assessed by statistical analysis using SPSS 16. Results: MAGE-1 expression was found in cancer cell cytoplasms of 30.1 of patients, with different degrees of intensity, (23.9 moderate and 6.2 strong). Nuclear staining turned positive in 31.8, stratified from moderate in 26.5to to strong in 5.3. There was a significant association between the number of lymph nodes involved and both nuclear (P = 0.042) and cytoplasmic (P = 0.003) MAGE-1 expression. There was also a significant correlation between the nuclear expression of MAGE-1 and tumor size (P = 0.018). Cytoplasmic expression of MAGE-1 increased with increasing pathologic grade of tumors although the association was not statistically significant (P = 0.119). Conclusions: CTA MAGE-1 has significant association with some prognostic factors in breast cancer and may have the role of a prognostic factor. © 2016, Iranian Journal of Cancer Prevention.

Item Type: Article
Additional Information: Cited By :5 Export Date: 16 February 2020 Correspondence Address: Fanipakdel, A.; Cancer Research Center, Faculty of Medicine, Mashhad University of Medical SciencesIran; email: fanipa@mums.ac.ir
Uncontrolled Keywords: Breast Cancer Cancer-Testis Antigens Immunohistochemistry MAGE-1 cancer testis antigen epidermal growth factor receptor 2 estrogen receptor melanoma antigen 1 progesterone receptor adult aged antigen expression antigen specificity Article cancer grading cancer immunotherapy cancer prognosis controlled study correlation analysis female histopathology human human tissue major clinical study protein expression tumor invasion tumor volume
Subjects: WP Gynecology
QZ pathology-neoplasms-Genetics
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib4 lib4
Date Deposited: 01 Mar 2020 04:40
Last Modified: 01 Mar 2020 04:40
URI: http://eprints.mums.ac.ir/id/eprint/13161

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