Efficacy of Statin Therapy in Pulmonary Arterial Hypertension: A Systematic Review and Meta-Analysis

Rysz-Górzynska, M. and Gluba-Brzózka, A. and Sahebkar, A. and Serban, M. C. and Mikhailidis, D. P. and Ursoniu, S. and Toth, P. P. and Bittner, V. and Watts, G. F. and Lip, G. Y. H. and Rysz, J. and Catapano, A. L. and Banach, M. (2016) Efficacy of Statin Therapy in Pulmonary Arterial Hypertension: A Systematic Review and Meta-Analysis. Scientific Reports, 6.

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Abstract

Since the evidence regarding statin therapy in PAH has not been conclusive, we assessed the impact of statin therapy in PAH through a systematic review and meta-analysis of available studies. We searched selected databases up to August 1, 2015 to identify the studies investigating the effect of statin administration on PAH. Meta-analysis was performed using either a fixed-effects or random-effect model according to I 2 statistic. Meta-analysis of 8 studies with 665 patients did not suggest any significant improvement in 6-min walking distance (6MWD) by statin therapy (weighed mean difference WMD:-6.08 m, 95% confidence interval CI:-25.66, 13.50, p = 0.543; Q = 8.41, I 2 = 28.64%). Likewise, none of the other indices including pulmonary arterial pressure (WMD:-0.97 mmHg, 95%CI:-4.39, 2.44, p = 0.577; Q = 14.64, I 2 = 79.51%), right atrial pressure (WMD: 1.01 mmHg, 95%CI:-0.93, 2.96, p = 0.307; Q = 44.88, I2 = 95.54%), cardiac index (WMD: 0.05 L/min/m2, 95%CI:-0.05, 0.15, p = 0.323; Q = 3.82, I 2 = 21.42%), and pulmonary vascular resistance (WMD:-1.42 dyn∗s/cm5, 95%CI:-72.11, 69.27, p = 0.969; Q = 0.69, I2 = 0%) was significantly altered by statin therapy. In conclusion, the results of the meta-analysis did not show a statistically significant effect of statin therapy in the improvement of 6MWD, pulmonary arterial pressure, right atrial pressure, cardiac index and pulmonary vascular resistance.

Item Type: Article
Additional Information: Cited By :16 Export Date: 16 February 2020 Correspondence Address: Banach, M.; Department of Hypertension, Medical University of LodzPoland; email: maciejbanach@aol.co.uk
Uncontrolled Keywords: hydroxymethylglutaryl coenzyme A reductase inhibitor arterial pressure female heart atrium pressure human male meta analysis pulmonary hypertension treatment outcome vascular resistance Atrial Pressure Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors Hypertension, Pulmonary
Subjects: WH Hemic and Lymphatic System
QU Biochemistry
QV pharmacology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib4 lib4
Date Deposited: 29 Feb 2020 08:50
Last Modified: 29 Feb 2020 08:50
URI: http://eprints.mums.ac.ir/id/eprint/13169

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