Evaluation of the prevalence rate and the prognostic effect of human papilloma virus infection in a group of patients with oral cavity squamous cell carcinoma

Saghravanian, N. and Zamanzadeh, M. and Meshkat, Z. and Aghaee, M. A. and Salek, R. (2016) Evaluation of the prevalence rate and the prognostic effect of human papilloma virus infection in a group of patients with oral cavity squamous cell carcinoma. International Journal of Cancer Management, 9 (3). pp. 1-8.

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Abstract

Background: Squamouscell carcinoma (SCC) is the mostcommonmalignancy of the oral cavity. Arelationship between thehuman papilloma virus (HPV) infection and the prognosis of oral cavity SCC (OCSCC) has been discussed before. Objectives: We investigated the prevalence rate of HPV status in patients with OCSCC, and its effects on clinicopathological characteristics of tumors and patients’ prognosis. Patients and Methods: Sections of formalin-fixed, paraffin-embedded tissue blocks from 114 histopathologically confirmed OCSCC cases were investigated in this study. Polymerase chain reaction (PCR) was applied to evaluate the HPV status in the samples. Results: Fifteen (13.16) cases were identified as HPV positive. The detected viral subtypes in this study were the subtypes 6 and 11. The stage and especially lymph node stage was significantly higher in the HPV positive group compared to the HPV negative group (P = 0.04). Disease free survival (DFS) was remarkably lower in the HPV positive group compared to the HPV negative group (13.9 vs. 49.9 months, P = 0.02). Overall survival (OS) was also significantly inferior in the HPV positive group (15.7 vs. 49.6 months, P = 0.01). In the current study, no significant differences were observed between two groups in relation to the variables of age, gender, tumors site, tumor size, tumor grading and also the recurrence rate. Conclusions: The observed higher mortality rate among the HPV positive group indicates the poorer prognosis of this group in comparison with theHPVnegative patients. The incidence rate of HPVinfectionwaslow in the studied samples; however, interaction of subtypes 6 and 11 of HPV in poorer prognosis of the patients and a carcinogenic role of HPV in OCSCC cannot be ruled out. © 2016, Iranian Journal of Cancer Prevention.

Item Type: Article
Additional Information: Cited By :5 Export Date: 16 February 2020 Correspondence Address: Salek, R.; Clinical Radiation Oncology, Cancer Research Center, Mashhad University of Medical SciencesIran; email: salekr@mums.ac.ir
Uncontrolled Keywords: Human Papilloma Virus Iran Oral Cavity Squamous Cell Carcinoma Polymerase Chain Reaction Prognosis adult aged Article cancer mortality cancer prognosis clinical article clinical feature controlled study disease free survival female histopathology human Human papillomavirus type 11 Human papillomavirus type 16 incidence male mouth squamous cell carcinoma overall survival papillomavirus infection prevalence tissue section virus carcinogenesis
Subjects: WC Communicable Diseases
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib4 lib4
Date Deposited: 29 Feb 2020 06:27
Last Modified: 29 Feb 2020 06:27
URI: http://eprints.mums.ac.ir/id/eprint/13179

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