Impact of statin therapy on plasma leptin concentrations: a systematic review and meta-analysis of randomized placebo-controlled trials

Sahebkar, A. and Giua, R. and Pedone, C. (2016) Impact of statin therapy on plasma leptin concentrations: a systematic review and meta-analysis of randomized placebo-controlled trials. British Journal of Clinical Pharmacology, 82 (6). pp. 1674-1684.

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Objectives: The effects of statins on insulin sensitivity, metabolic homeostasis and adipokines in humans are controversial. Several studies have investigated the impact of statin therapy on plasma leptin concentrations but the results have been inconsistent. The aim of the present study was to conduct a systematic review and meta-analysis of available evidence to calculate the effect size of statin therapy in changing serum leptin concentrations. Methods: A systematic search in PubMed-Medline, SCOPUS, Web of Science and Google Scholar databases was performed to identify randomized placebo-controlled trials investigating the effect of statins on plasma leptin concentrations. A random-effects model and generic inverse variance method were used for meta-analysis. Sensitivity analysis, risk-of-bias evaluation and publication bias assessment were carried out using standard methods. Random-effects meta-regression was used to evaluate the impact of treatment duration on the estimated effect size. Results: Six trials, with a total of 425 subjects, met the eligibility criteria. Overall, statin therapy had no significant effect on leptin levels (weighted mean difference −0.32 ng ml–1, 95 confidence nterval: −2.94, 2.30, P = 0.813). This effect was robust in the sensitivity analysis and in subgroup analyses of trials with <12 or ≥12 weeks' duration. There was no association between the duration of statin therapy and changes in plasma leptin levels. Furthermore, there was no differential effect of hydrophilic and lipophilic statins on plasma leptin concentrations. Conclusion: Unless more consistent evidence becomes available in the future, the hypothesis of a relationship between statin use and serum leptin concentrations seem to be unfounded. © 2016 The British Pharmacological Society

Item Type: Article
Additional Information: Cited By :5 Export Date: 16 February 2020 CODEN: BCPHB Correspondence Address: Pedone, C.; Area di Geriatria, Policlinico Universitario Campus Bio-MedicoItaly; email:
Uncontrolled Keywords: insulin resistance leptin statin hydroxymethylglutaryl coenzyme A reductase inhibitor Article drug effect hormone blood level human hydrophilicity lipophilicity meta analysis priority journal randomized controlled trial (topic) systematic review treatment duration blood dose response hypercholesterolemia statistical analysis Data Interpretation, Statistical Dose-Response Relationship, Drug Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors Randomized Controlled Trials as Topic
Subjects: QV pharmacology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib4 lib4
Date Deposited: 29 Feb 2020 06:49
Last Modified: 29 Feb 2020 06:49

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