Analgesic efficacy and safety of curcuminoids in clinical practice: A systematic review and meta-analysis of randomized controlled trials

Sahebkar, A. and Henrotin, Y. (2016) Analgesic efficacy and safety of curcuminoids in clinical practice: A systematic review and meta-analysis of randomized controlled trials. Pain Medicine (United States), 17 (6). pp. 1192-1202.

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Abstract

Background. Curcuminoids are natural products with potent anti-inflammatory and antioxidant properties. There have been a number of reports on the analgesic effects of curcuminoids in clinical trials, yet data have not been fully conclusive. Objectives. To provide the highest level of evidence on the efficacy of curcuminoids in patients with painful conditions through meta-analysis of data from randomized controlled trials (RCTs). Methods. A systematic review and meta-analysis was conducted using data reported by RCTs. The primary efficacy measure was pain intensity or algofunctional status. Treatment effect was summarized with standardized mean difference (SMD) calculated from differences in means of pain measures between treatment and control groups using a random- effects model. Results. A total of eight RCTs met our inclusion criteria that included 606 randomized patients. Curcuminoids were found to significantly reduce pain (SMD:20.57, 95 CI:21.11 to20.03, P50.04). This pain-relieving effect was found to be independent of administered dose and duration of treatment with curcuminoids, and was free from publication bias. Curcuminoids were safe and well tolerated in all evaluated RCTs. Conclusion. Curcuminoids supplements may be a safe and effective strategy to improve pain severity, by warranting further rigorously conducted studies to define the long-term efficacy and safety. © 2015 American Academy of Pain Medicine. All rights reserved.

Item Type: Article
Additional Information: Cited By :85 Export Date: 16 February 2020 CODEN: PMAEA Correspondence Address: Henrotin, Y.; Bone and Cartilage Research Unit, Arthropôle Liege, University of Liege, CHU Sart-Tilman, Belgium; email: yhenrotin@ulg.ac.be
Uncontrolled Keywords: Curcumin Curcuminoids Effect size Meta-analysis Pain analgesic agent Curcuma longa extract curcuminoid derivative diclofenac ibuprofen natural product placebo unclassified drug plant extract abdominal distension abdominal pain analgesic activity clinical practice Curcuma longa drug absorption drug bioavailability drug efficacy drug safety drug tolerability dyspepsia edema fever functional status gastrointestinal symptom human knee osteoarthritis long term care loose feces meta analysis muscle injury nausea pain assessment pain intensity pain severity pancreatitis pharyngitis pitting edema randomized controlled trial (topic) Review rheumatoid arthritis systematic review treatment duration unspecified side effect visual analog scale vomiting analgesia procedures Analgesics Humans Pain Management Plant Extracts Randomized Controlled Trials as Topic
Subjects: QV pharmacology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib4 lib4
Date Deposited: 29 Feb 2020 06:54
Last Modified: 29 Feb 2020 06:54
URI: http://eprints.mums.ac.ir/id/eprint/13183

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