The effects of Nigella sativa on neural damage after pentylenetetrazole induced seizures in rats

Seghatoleslam, M. and Alipour, F. and Shafieian, R. and Hassanzadeh, Z. and Edalatmanesh, M. A. and Sadeghnia, H. R. and Hosseini, M. (2016) The effects of Nigella sativa on neural damage after pentylenetetrazole induced seizures in rats. Journal of Traditional and Complementary Medicine, 6 (3). pp. 262-268.

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Abstract

Nigella sativa (NS) has been suggested to have neuroprotective and anti-seizures properties. The aim of current study was to investigate the effects of NS hydro-alcoholic extract on neural damage after pentylenetetrazole (PTZ) – induced repeated seizures. The rats were divided into five groups: (1) control (saline), (2) PTZ (50 mg/kg, i.p.), (3–5) PTZ-NS 100, PTZ-NS 200 and PTZ-NS 400 (100, 200 and 400 mg/kg of NS extract respectively, 30 min prior to each PTZ injection on 5 consecutive days). The passive avoidance (PA) test was done and the brains were then removed for histological measurements. The PTZ-NS 100, PTZ-NS 200 and PTZ-NS 400 groups had lower seizure scores than PTZ group (P < 0.01 and P < 0.001). The latency to enter the dark compartment by the animals of PTZ group was lower than control in PA test (P < 0.01). Pre-treatment by 400 mg/kg of the extract increased the latency to enter the dark compartment (P < 0.05). Meanwhile, different doses of the extract inhibited production of dark neurons in different regions of hippocampus (P < 0.001). The present study allows us to suggest that the NS possesses a potential ability to prevent hippocampal neural damage which is accompanied with improving effects on memory. © 2016 Center for Food and Biomolecules, National Taiwan University

Item Type: Article
Additional Information: Cited By :21 Export Date: 16 February 2020 Correspondence Address: Hosseini, M.; Department of Physiology, School of Medicine, Mashhad University of Medical SciencesIran; email: hosseinim@mums.ac.ir
Uncontrolled Keywords: Neural damage Nigella sativa Pentylenetetrazole Rat Repeated seizures
Subjects: WL Nervous system
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib4 lib4
Date Deposited: 26 Feb 2020 11:10
Last Modified: 26 Feb 2020 11:10
URI: http://eprints.mums.ac.ir/id/eprint/13195

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