Exosomes as nanocarriers for siRNA delivery: Paradigms and challenges

Shahabipour, F. and Banach, M. and Sahebkar, A. (2016) Exosomes as nanocarriers for siRNA delivery: Paradigms and challenges. Archives of Medical Science, 12 (6). pp. 1324-1326.

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Abstract

Exosomes are nano-sized vesicles that facilitate intercellular communications through carrying genetic materials and functional biomolecules. Owing to their unique size and structure, exosomes have emerged as a useful tool to overcome the limitations of siRNA delivery. The use of exosomes as siRNA delivery vehicles lacks certain disadvantages of the existing foreign delivery systems such as viruses, polycationic polymers and liposomes, and introduces several advantages including inherent capacity to pass through biological barriers and escape from phagocytosis by the reticuloendothelial system, as well as being biocompatible, non-Toxic, and immunologically inert. Different strategies have been employed to harness exosome-based delivery systems, including surface modification with targeting ligands, and using exosome-display technology, virus-modified exosomes, and exosome-mimetic vesicles. The present review provides a capsule summary of the recent advances and current challenges in the field of exosome-mediated siRNA delivery. © 2016 Termedia & Banach.

Item Type: Article
Additional Information: Cited By :16 Export Date: 16 February 2020 Correspondence Address: Sahebkar, A.; Biotechnology Research Center, Mashhad University of Medical Sciences, Vakilabad Blvd., Iran; email: sahebkara@mums.ac.ir
Uncontrolled Keywords: Drug delivery Exosome Gene therapy Microrna Nanomedicine Sirna cell penetrating peptide Lamp2b protein lipofectamine liposome lysosome associated membrane protein 2 nanocarrier polyethyleneimine small interfering RNA unclassified drug virus glycoprotein Article cell transport electroporation gene delivery system gene silencing genetic transfection human macrophage monocyte nonhuman RNA sequence virus
Subjects: QU Biochemistry
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib4 lib4
Date Deposited: 29 Feb 2020 04:52
Last Modified: 29 Feb 2020 04:52
URI: http://eprints.mums.ac.ir/id/eprint/13200

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