Ki67 frequency in breast cancers without axillary lymph node involvement and its relation with disease-free survival

Shandiz, F. H. and Shabahang, H. and Afzaljavan, F. and Sharifi, N. and Tavasoli, A. and Afzalaghaee, M. and Roshanzamir, E. and Pasdar, A. (2016) Ki67 frequency in breast cancers without axillary lymph node involvement and its relation with disease-free survival. Asian Pacific Journal of Cancer Prevention, 17 (3). pp. 1347-1350.

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Background: Breast cancer prognosis is influenced by several histopathology and clinical factors including expression of Ki67 which may have a predictive role in lymph node negative breast cancer patients. The aim of this study was to assess Ki67 expression in breast cancers without axillary lymph node involvement and to evaluate its prognostic value with regard to disease-free survival. Materials and Methods: Subjects were selected from non-metastatic invasive breast cancer patients who were referred to the oncology department of Ghaem hospital during 1 April 2001 to 1 April 2008. Ki67 levels were measured using immunohistochemistry (IHC) and compared with clinicopathological features. The relation of Ki67 expression with disease-free survival was also analysed. Results: A total of 106 women with a mean age of 49 were examined. Some 94.3 were classified as having invasive ductal carcinomas and the mean tumour diameter at the time of diagnosis was 2.8 cm. Some 50.9 of cases were ER positive and 47.2 were PR positive. P53 expression was positive in 48.1 of the cases. According to the IHC results, only 8.5 of the patients were Her2/neu positive. Ki67 was positive in 66 (62.3) with a significant relation to lower age (p=0.0229) and P53 positivity (p=0.005). After an average of 40-months follow up, 13 (12.3) demonstrated recurrence, most commonly systemic. Of 13 cases with relapse, 10 patients (77) were Ki67 positive. Conclusions: In our population Ki67 appeared to be an independent prognostic factor for three-year survival. However, we stress that a survival study with a bigger sample size would help to support this conclusion.

Item Type: Article
Additional Information: Cited By :4 Export Date: 16 February 2020 Correspondence Address: Pasdar, A.; Department of Modern Sciences and Technologies, Faculty of Medicine, Mashhad University of Medical SciencesIran; email:
Uncontrolled Keywords: Breast cancer Disease-free survival Ki67 Negative axillary lymph node epidermal growth factor receptor 2 estrogen receptor Ki 67 antigen progesterone receptor tumor marker adult aged breast tumor cancer grading cancer staging enzyme immunoassay female follow up human lung carcinoma lymph node metabolism middle aged mortality Paget nipple disease pathology prognosis retrospective study survival rate tumor invasion tumor recurrence Biomarkers, Tumor Breast Neoplasms Carcinoma, Ductal, Breast Carcinoma, Lobular Follow-Up Studies Humans Immunoenzyme Techniques Ki-67 Antigen Lymph Nodes Neoplasm Grading Neoplasm Invasiveness Neoplasm Recurrence, Local Neoplasm Staging Receptor, ErbB-2 Receptors, Estrogen Receptors, Progesterone Retrospective Studies
Subjects: WP Gynecology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib4 lib4
Date Deposited: 26 Feb 2020 09:27
Last Modified: 26 Feb 2020 09:27

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