HER2 gene amplification in patients with prostate cancer: Evaluating a CISH-based method

Sharifi, N. and Salmaninejad, A. and Ferdosi, S. and Bajestani, A. N. and Khaleghiyan, M. and Estiar, M. A. and Jamali, M. and Nowroozi, M. R. and Shakoori, A. (2016) HER2 gene amplification in patients with prostate cancer: Evaluating a CISH-based method. Oncology Letters, 12 (6). pp. 4643-4650.

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Abstract

Prostate cancer (PCa) is one of the most widespread malignancies in the world. The role of the human epidermal growth factor receptor 2 (HER2) in the pathogenesis and progression of human PCa remains poorly understood. In contradiction with breast cancer, studies on HER2 overexpression and gene amplification in PCa have produced varying results, although the HER2 oncogene has been implicated in the biology of numerous tumor types, and serves as a prognostic marker and therapeutic target in breast cancer. Technical challenges are considered the main reasons for data discrepancies. Amplification of the HER2 gene has previously been reported in PCa, in which it was associated with tumor progression. The present study aimed to evaluate the prevalence and clinical significance of HER2 amplification in PCa. A total of 32 biopsy samples obtained from human prostate adenocarcinomas were evaluated by chromogenic in situ hybridization (CISH) to determine the frequency of patients with HER2 gene amplifications. High copy numbers of HER2 were detected in 19 of the prostate tumors analyzed. The results of the present study suggested that, in patients without amplification of HER2, high levels of prostate-specific antigen or a high Gleason score were not significantly correlated with a high pathologic stage. Furthermore, amplification levels of the HER2 gene were directly associated with pathologic stage in patients with PCa. Therefore, the potential use of HER2 as a prognostic factor or therapeutic target for PCa warrants further study. © 2016, Spandidos Publications. All rights reserved.

Item Type: Article
Additional Information: Cited By :3 Export Date: 16 February 2020 Correspondence Address: Shakoori, A.; Department of Medical Genetics, Cancer Institute of Iran, Tehran University of Medical SciencesIran; email: shakooria@tums.ac.ir
Uncontrolled Keywords: Amplification Chromogenic in situ hybridization References Gene Human epidermal growth factor receptor 2 Prostate cancer epidermal growth factor receptor 2 prostate specific antigen adult aged Article chromogenic in situ hybridization clinical article controlled study gene amplification gene dosage Gleason score human human tissue in situ hybridization male microscopy middle aged pathology prostate adenocarcinoma very elderly
Subjects: WJ Urogenital System
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib4 lib4
Date Deposited: 26 Feb 2020 09:50
Last Modified: 26 Feb 2020 09:50
URI: http://eprints.mums.ac.ir/id/eprint/13210

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