Effects of dimethyl sulfoxide on neuronal response characteristics in deep layers of rat barrel cortex

Soltani, N. and Mohammadi, E. and Allahtavakoli, M. and Shamsizadeh, A. and Roohbakhsh, A. and Haghparast, A. (2016) Effects of dimethyl sulfoxide on neuronal response characteristics in deep layers of rat barrel cortex. Basic and Clinical Neuroscience, 7 (3). pp. 213-220.

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Introduction: Dimethyl sulfoxide (DMSO) is a chemical often used as a solvent for water-insoluble drugs. In this study, we evaluated the effect of intracerebroventricular (ICV) administration of DMSO on neural response characteristics (in 1200-1500 μm depth) of the rat barrel cortex. Methods: DMSO solution was prepared in 10 v/v concentration and injected into the lateral ventricle of rats. Neuronal spontaneous activity and neuronal responses to deflection of the principal whisker (PW) and adjacent whisker (AW) were recorded in barrel cortex. A condition test ratio (CTR) was used to measure inhibitory receptive fields in barrel cortex. Results: The results showed that both PW and AW evoked ON and OFF responses, neuronal spontaneous activity and inhibitory receptive fields did not change following ICV administration of DMSO. Conclusion: Results of this study suggest that acute ICV administration of 10 DMSO did not modulate the electrophysiological characteristics of neurons in the 1 deep ayers of rat barrel cortex.

Item Type: Article
Additional Information: Cited By :2 Export Date: 16 February 2020 Correspondence Address: Shamsizadeh, A.; Physiology-Pharmacology Research Center, Rafsanjan University of Medical SciencesIran; email: alishamsy@gmail.com
Uncontrolled Keywords: DMSO Electrophysiology Rats Somatosensory cortex dimethyl sulfoxide adjacent whisker animal cell animal experiment animal tissue Article condition test ratio controlled study deep layer barrel cortex excitatory receptive field inhibitory receptive field intracerebroventricular drug administration male mechanical stimulation nerve cell nervous system electrophysiology neuromodulation neuronal spontaneous activity nonhuman parameters principal whisker rat receptive field solvent effect vibrissa
Subjects: WL Nervous system
QV pharmacology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib4 lib4
Date Deposited: 26 Feb 2020 07:13
Last Modified: 26 Feb 2020 07:13
URI: http://eprints.mums.ac.ir/id/eprint/13221

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