Association of p53/p21 expression with cigarette smoking and prognosis in esophageal squamous cell carcinoma patients

Taghavi, N. and Biramijamal, F. and Sotoudeh, M. and Moaven, O. and Khademi, H. and Abbaszadegan, M. R. and Malekzadeh, R. (2010) Association of p53/p21 expression with cigarette smoking and prognosis in esophageal squamous cell carcinoma patients. World Journal of Gastroenterology, 16 (39). pp. 4958-4967.

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AIM: To investigate the expression of p53 and p21 and associations with possible risk factors, such as cigarette smoking, in esophageal squamous cell carcinoma (ESCC) in northeastern Iran, a region with a high incidence of ESCC. METHODS: The expression of p53 and p21 proteins was investigated immunohistochemically in tumor tissue from 80 ESCC patients and in 60 available paraffinembedded blocks of adjacent normal specimens from the cases, along with normal esophageal tissue from 80 healthy subjects. RESULTS: Positive expression of p53 protein was detected in 56.2 (45/80) of ESCC cases, and in none of the normal esophageal tissue of the control group (P < 0.001). Furthermore, 73.8 (59/80) of ESCC cases and 43.8 (35/80) of controls had positive expression of p21 protein (P < 0.001). Cigarette smoking was significantly associated with p53 over-expression in ESCC cases (P = 0.010, OR = 3.64; 95 CI: 1.32-10.02). p21 over-expression was associated with poorer clinical outcome among the ESCC patients (P = 0.009). CONCLUSION: Over-expression of p53 in association with cigarette smoking may play a critical role in ESCC carcinogenesis among this high-risk population of northeastern Iran. Furthermore, p21 over-expression was found to be associated with poor prognosis, specifically in the operable ESCC patients. © 2010 Baishideng.

Item Type: Article
Additional Information: Cited By :31 Export Date: 16 February 2020 CODEN: WJGAF Correspondence Address: Biramijamal, F.; Department of Medical Genetics, National Institute of Genetic Engineering and Biotechnology, 17km, Tehran-Karaj High way, PO Box 14965/161, Tehran 14977-16316, Iran; email:
Uncontrolled Keywords: Esophageal squamous cell carcinoma Immunohistochemistry p21 p53 Smoking Survival protein p21 protein p53 adult article cancer survival cigarette smoking controlled study correlation analysis esophagus carcinoma female human major clinical study male prognosis protein expression squamous cell carcinoma Aged Aged, 80 and over Carcinoma, Squamous Cell Case-Control Studies Chi-Square Distribution Cyclin-Dependent Kinase Inhibitor p21 Esophageal Neoplasms Humans Incidence Iran Kaplan-Meier Estimate Logistic Models Middle Aged Odds Ratio Proportional Hazards Models Risk Assessment Risk Factors Tumor Markers, Biological Tumor Suppressor Protein p53
Subjects: QS Human Anatomy
WI Digestive System
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib4 lib4
Date Deposited: 26 Feb 2020 07:35
Last Modified: 26 Feb 2020 07:35

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