Selenium supplementation and the incidence of preeclampsia in pregnant Iranian women: A randomized, double-blind, placebo-controlled pilot trial

Tara, F. and Maamouri, G. and Rayman, M. P. and Ghayour-Mobarhan, M. and Sahebkar, A. and Yazarlu, O. and Ouladan, S. and Tavallaie, S. and Azimi-Nezhad, M. and Shakeri, M. T. and Boskabadi, H. and Oladi, M. and Sangani, M. T. and Razavi, B. S. and Ferns, G. (2010) Selenium supplementation and the incidence of preeclampsia in pregnant Iranian women: A randomized, double-blind, placebo-controlled pilot trial. Taiwanese Journal of Obstetrics and Gynecology, 49 (2). pp. 181-187.

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Objective: Recent studies have reported that antioxidant status, including serum selenium concentrations, is altered in women who develop preeclampsia. We wished to examine the effects of selenium supplementation in the prevention of preeclampsia in high-risk pregnant women. Design: We carried out a randomized, double-blind, placebo-controlled pilot trial. A total of 166 primigravid pregnant women, who were in the first trimester of pregnancy, were randomized to receive 100 μg of selenium (n = 83; dropouts, n = 22) or a placebo (n = 83; dropouts, n = 19) per day until delivery. The incidence of preeclampsia, serum selenium concentrations, lipid profile and high-sensitivity C-reactive protein status were evaluated at baseline and at the end of the study. Results: Supplementation with selenium was not associated with any reported major side effects and was associated with a significant increase in mean serum selenium concentrations at term (p < 0.001). In contrast, mean serum selenium concentrations remained unchanged in the control group (p = 0.63). The incidence of preeclampsia was lower in the selenium group (n = 0) than in the control group (n = 3), although this was not statistically significant (p > 0.05). After treatment, systolic and diastolic blood pressure, serum total cholesterol, triglycerides, low-density and high-density lipoprotein cholesterol, and high-sensitivity C-reactive protein were significantly increased in both groups compared with pretreatment levels (p < 0.05). Conclusion: Our findings indicate that selenium supplementation in pregnant women may be associated with a lower frequency of preeclampsia. © 2010 Taiwan Association of Obstetrics and Gynecology.

Item Type: Article
Additional Information: Cited By :50 Export Date: 16 February 2020 Correspondence Address: Ghayour-Mobarhan, M.; Cardiovascular Research Center, Avicenna Research Institute, Mashhad University of Medical Sciences, P.O. Box 91775-379, Mashhad, Iran; email:
Uncontrolled Keywords: High-sensitivity C-reactive protein Lipid Preeclampsia Pregnancy Selenium C reactive protein cholesterol low density lipoprotein cholesterol placebo triacylglycerol absence of side effects adolescent adult anthropometric parameters article blood pressure measurement body height body mass body weight cholesterol blood level clinical trial comparative study controlled clinical trial controlled study delivery diastolic blood pressure double blind procedure drug blood level drug effect female first trimester pregnancy high risk population high risk pregnancy human incidence Iran lipid blood level major clinical study pregnant woman primigravida protein blood level proteinuria randomized controlled trial supplementation systolic blood pressure triacylglycerol blood level waist circumference waist hip ratio Antioxidants Blood Pressure C-Reactive Protein Double-Blind Method Humans Lipoproteins, HDL Lipoproteins, LDL Pilot Projects Pre-Eclampsia Pregnancy Trimester, First Triglycerides
Subjects: WQ Obstetrics
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib4 lib4
Date Deposited: 04 Mar 2020 04:32
Last Modified: 04 Mar 2020 04:32

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