Evaluation of mechanism for antihypertensive and vasorelaxant effects of hexanic and hydroalcoholic extracts of celery seed in normotensive and hypertensive rats

Tashakori-Sabzevar, F. and Razavi, B. M. and Imenshahidi, M. and Daneshmandi, M. and Fatehi, H. and Sarkarizi, Y. E. and Mohajeri, S. A. (2016) Evaluation of mechanism for antihypertensive and vasorelaxant effects of hexanic and hydroalcoholic extracts of celery seed in normotensive and hypertensive rats. Brazilian Journal of Pharmacognosy, 26 (5). pp. 619-626.

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Abstract

Celery (Apium graveolens L., Apiaceae) is one of the popular aromatic vegetables and part of the daily diet around the world. In this study, aqueous-ethanolic and hexane extracts of celery seed were prepared and the amount of n-butylphthalide, as an active component, was determined in each extract. Then the effects of hexanic extract on systolic, diastolic, mean arterial blood pressure and heart rate were evaluated in an invasive rat model. The vasodilatory effect and possible mechanisms of above mentioned extracts on aorta ring were also measured. High performance liquid chromatography analysis revealed that hexanic extract contains significantly higher amounts of n-butylphthalide, compared to aqueous-ethanolic extract. The results indicated that hexanic extract significantly decreased the systolic, diastolic, mean arterial blood pressure and heart rate in normotensive and hypertensive rats. Our data revealed that celery seed extract exerts its hypotensive effects through its bradycardic and vasodilatory properties. Moreover, the active components in celery seed extracts could induce their vasodilatory properties through Ca2+ channel blocking activity in endothelial and non-endothelial pathways and particularly by interference with the extra or intracellular calcium. © 2016 Sociedade Brasileira de Farmacognosia.

Item Type: Article
Additional Information: Cited By :2 Export Date: 16 February 2020 Correspondence Address: Mohajeri, S.A.; Pharmaceutical Research Center, School of Pharmacy, Mashhad University of Medical SciencesIran; email: mohajeria@mums.ac.ir
Uncontrolled Keywords: Celery seed Heart rate Hypotensive effects Invasive model Isolated rat aorta Mean arterial blood pressure acetylcholine alcohol antihypertensive agent celery seed extract deoxycorticosterone acetate heparin hexane indometacin ketamine methanol mineralocorticoid nifedipine phenylephrine plant extract potassium chloride sodium chloride unclassified drug vasodilator agent xylazine animal experiment animal model animal tissue Apiaceae Article bradycardia celery controlled study diastolic blood pressure high performance liquid chromatography hypertension male mean arterial pressure nonhuman plant seed rat systolic blood pressure vasodilatation
Subjects: WH Hemic and Lymphatic System
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib4 lib4
Date Deposited: 04 Mar 2020 04:31
Last Modified: 04 Mar 2020 04:31
URI: http://eprints.mums.ac.ir/id/eprint/13231

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