Echocardiographic test and the early detection of systolic failure in systemic sclerosis patients: Strain and strain rate echocardiography

Yazdi, Z. R. and Fazlinezhad, A. and Bigdelu, L. and Sani, F. A. and Yazdi, G. T. and Izanloo, A. (2016) Echocardiographic test and the early detection of systolic failure in systemic sclerosis patients: Strain and strain rate echocardiography. Razavi International Journal of Medicine, 4 (3).

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Background: Pulmonary arterial hypertension (PAH) is a leading cause of death in systemic sclerosis (SSc) patients. Early detection of systolic failure in SSc patients will facilitate early treatment and improve the survival rate of these patients. Objectives: In this study, besides studying the RV function in SSC patients, attempts have been made to find a new possible noninvasive echocardiographic test for early diagnosis of systolic failure as a PAH complication. Methods: 30 patients with at least a 2-year history of diffuse SSc confirmed by an expert rheumatologist were enrolled in this study. All the patients underwent transthoracic echocardiography by an echocardiologist. Fractional area change (FAC) of the right ventricle (RV), tricuspid annular plane systolic excursion (TAPSE), RV lateral wall strain and strain rate (Base, Mid, Apex), RV-EDD and RV pressure with respect to inferior vena cava (IVC) diameter as well as Left Ventricle’s Ejection Fraction (LVEF) were evaluated. Results: The prevalence rate of PAH was reported 36.6 in this study. There was no significant relationship between LVEF and RV parameters. LVEF was found to be significantly higher in women whereas RV strain turned out to be higher in men. Besides, there was a significant relation between pulmonary arterial pressure (PAP) and Basal (P = 0.03), mid RV strain (P = 0.002), RV strain rate (P = 0.001) and RV diameter (P = 0.02). Also, an inverse relation was observed between RV systolic (P = 0.01) and diastolic functions (P = 0.007) with PAP. In addition, no significant relationship was found between LVEF and body mass index (BMI) and RV parameters (P > 0.05). Moreover, Apical RV strain and LVEF were found to be higher in males and females respectively. Furthermore, a significant relationship was found between RV strain and age (P = 0.027). Finally, the results did not show any relationship between RV systolic and diastolic functions and gender. Conclusions: This paper states the likely advantages of strain and strain rate echocardiography in identifying patients with more diffused and severe SSc and the need for further longitudinal studies based on the mentioned method for early diagnosis of myocardial impairment. © 2016, Razavi Hospital.

Item Type: Article
Additional Information: Export Date: 16 February 2020 Correspondence Address: Fazlinezhad, A.; Cardiovascular Research Center, Mashhad University of Medical SciencesIran; email:
Uncontrolled Keywords: Pulmonary arterial hypertension (PAH) Right ventricle (RV) function Scleroderma Strain and strain rate echocardiography Systemic sclerosis (SSc) Systolic failure Tissue doppler imaging (TDI) adolescent adult aged Article body mass clinical article female heart left ventricle ejection fraction heart right ventricle function heart right ventricle outflow tract hospitalization human inferior cava vein lung artery pressure male prevalence pulmonary hypertension sclerosis systolic dysfunction tissue Doppler imaging transthoracic echocardiography
Subjects: WG Cardiovascular System
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib4 lib4
Date Deposited: 04 Mar 2020 04:34
Last Modified: 04 Mar 2020 04:34

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