Role of BRCA1 and BRCA2 genes in risk of breast cancer

Kooshyar, Mohammad Mahdi and Nasiri, Mohammad Reza and Nasiri, Khadijeh (2016) Role of BRCA1 and BRCA2 genes in risk of breast cancer. The Iranian Journal of Obstetrics, Gynecology and Infertility, 19 (19). pp. 25-38.

IJOGI_Volume 19_Issue 19_Pages 25-38.pdf

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Introduction: Gene mutations of BRCA1 and BRCA2 in germline can cause risk of breast and ovarian cancers. BRCA1 and BRCA2 genes cause 20 of hereditary breast cancer. The majority of BRCA1 and BRCA2 mutations lead to premature protein termination. This study was performed with aim to investigate the role of BRCA1/2 mutations in risk of breast cancer and introduce some mutations associated with these genes. Methods: In this systematic review, the information related to the role of BRCA1/2 genes in risk of breast cancer was obtained by searching in databases of PubMed, Scopus, Med-Line, Web of Science, Science Iranian Database and other related websites using the keywords of BRCA mutation, BRCA1, BRCA2, breast cancer and Iran during 1990 to 2015. Finally, 88 articles were chosen that were associated with BRCA1 and BRCA2 genes and their role in risk of breast cancer Results: This review paper shows more than ever importance of identifying the gene mutations of BRCA1 and BRCA2 carriers in different societies, especially in national and the necessity of planning for families with family history of breast cancer and also screening for mutations in these two genes is felt in clinical programs of the country. Conclusion: BRCA1/2 genes have great importance and impact on the development and progression of breast cancer. Therefore, these genes can be considered as molecular markers in early detection of breast cancer.

Item Type: Article
Subjects: WP Gynecology
WQ Obstetrics
Divisions: Journals > Iranian J Obstetrics, Gynecology and Infertility
Depositing User: ijogi ijogi
Date Deposited: 19 Sep 2017 14:21
Last Modified: 19 Sep 2017 14:21

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