Evaluation of the Presencs of HHV7 DNA in Oral Lichenplanus Lesions by Polymerase Chain Reaction Method

Ghalayani, Parichehr and Sarrafan, Negar and Amini, Laleh and Alikhani, Milad (2016) Evaluation of the Presencs of HHV7 DNA in Oral Lichenplanus Lesions by Polymerase Chain Reaction Method. Journal of Mashhad Dental School, 40 (4). pp. 365-370.

[img]
Preview
Text
JMDS_Volume 40_Issue 4_Pages 365-370.pdf

Download (411kB) | Preview
Official URL: http://jmds.mums.ac.ir/article_7494.html

Abstract

Introduction: Oral lichen planus (OLP) is a common inflammatory disease with an unknown etiology; nevertheless, involvement of viral agents has been suggested in the literature. Human herpesvirus-7 (HHV-7) is a distinctive virus with a 90 global prevalence. It is a member of the Herpesviridae family and Betaherpesvirinae subfamily. Previous studies have confirmed the role of HHV-7 in cutaneous lichen planus lesions. Accordingly, the aim of this study was to evaluate the frequency of HHV-7 DNA genome in OLP lesions, using real-time polymerase chain reaction (PCR) method. Materials & Methods: A total of 30 paraffin blocks from OLP lesions, as well as 30 samples from the normal mucosa, were collected from patients, referring to dental care clinics of Isfahan, Iran. The samples were evaluated for HHV-7 DNA genome, using the conventional PCR method. Data were analyzed via McNemar’s test, and the significance level was set at P=0.05. Results: A total of 10 out of 30 samples from OLP lesions showed positive HHV-7 DNA genome, while none of the control samples showed viral presence. Conclusions: There was a significant relationship between HHV-7 infection and OLP occurrence (P=0.002).

Item Type: Article
Subjects: WU Dentistry. Oral surgery
Divisions: Journals > Journal of Mashhad Dental School
Depositing User: jmds jmds
Date Deposited: 20 Sep 2017 12:41
Last Modified: 20 Sep 2017 12:41
URI: http://eprints.mums.ac.ir/id/eprint/1492

Actions (login required)

View Item View Item