Intratympanic Injection of Dexamethasone and Electrocochleographic Data in Cases of Definite One Sided Refractory Meniere's Disease

Dabiri Satri, Sasan and Gharibi, Reza and Nevadian, Farzane and Yazdani, Nasrin and Hoseinabadi, Reza and Rezazade, Nima and Firouzifar, Mohammad Reza and Babaei, Saeed (2017) Intratympanic Injection of Dexamethasone and Electrocochleographic Data in Cases of Definite One Sided Refractory Meniere's Disease. Iranian Journal of Otorhinolaryngology, 29 (3). pp. 121-125.

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Abstract

Introduction: Meniere's disease (MD) is a disease of the inner ear that presents itself with repeated episodes of vertigo (96.2), tinnitus (91.1), and sensorineural hearing loss (87.7 ). In this article we sought to assess the effects of intratympanic (IT) injections of dexamethasone on definite cases of MD using electrocochleography (ECOG). Materials and Methods: In this hospital-based case series in 36 patients, we measured audiometric values and ECOG in all patients before, 1 month and 6 months after 4-mg/mL IT injections of dexamethasone. Results: Four patients (11) had improved hearing following the intervention. No difference in pure tone audiometry (PTA) was observed following IT injections (P=0.492), while speech discrimination score (SDS) was significantly improved (P=0.008). There was a significant improvement in vertigo 1 month after IT injections (P<0.001), although this effect did not last for 6 months. No significant change in ECOG was observed between before and after treatment (P=0.052). Conclusion: IT dexamethasone injections can improve vertigo in definite cases of MD, although it seems that the effect is only temporary.

Item Type: Article
Subjects: WV Otolaryngology
Divisions: Journals > Iranian J Otorhinolaryngology
Depositing User: ijo ijo
Date Deposited: 20 Sep 2017 12:42
Last Modified: 20 Sep 2017 12:42
URI: http://eprints.mums.ac.ir/id/eprint/1508

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