The effects of Nigella sativa on sickness behavior induced by lipopolysaccharide in male Wistar rats

Norouzi, Fatemeh and Abareshi, Azam and Anaeigoudari, Akbar and Shafei, Mohammad Naser and Gholamnezhad, Zahra and Saeedjalali, Mohsen and Mohebati, Reza and Hosseini, Mahmoud (2016) The effects of Nigella sativa on sickness behavior induced by lipopolysaccharide in male Wistar rats. Avicenna Journal of Phytomedicine, 6 (1). pp. 104-116.

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Abstract

Objective: Neuroimmune factors contribute on the pathogenesis of sickness behaviors. Nigella sativa (NS) has anti-inflammatory, anti-anxiety and anti-depressive effects. In the present study, the effect of NS hydro-alcoholic extract on sickness behavior induced by lipopolysaccharide (LPS) was investigated. Materials and Methods: The rats were divided into five groups (n=10 in each): (1) control (saline), (2) LPS (1 mg/kg, administered two hours before behavioral tests), (3-5) LPS-Nigella sativa 100 , 200 and 400 mg/kg (LPS-NS 100, LPS-NS 200 and LPS-NS 400, respectively). Open- field (OF), elevated plus maze (EPM) and forced swimming test (FST) were performed. Results: In OF, LPS reduced the peripheral crossing, peripheral distance, total crossing and total distance compared to control (pConclusion: The results of the present study showed that the hydro-alcoholic extract of NS reduced the LPS-induced sickness behaviors in rats. Further investigations are required for better understanding the responsible compound (s) and the underlying mechanism(s).

Item Type: Article
Subjects: QU Biochemistry
Divisions: Journals > Avicenna J Phytomedicine
Depositing User: ajp ajp
Date Deposited: 20 Sep 2017 15:57
Last Modified: 20 Sep 2017 15:57
URI: http://eprints.mums.ac.ir/id/eprint/1529

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