Inhibitory effect of Crocus sativus L. ethanol extract on adjuvant-induced arthritis

Zamani Taghizadeh Rabe, S. and Sahebari, M. and Mahmoudi, Z. and Hosseinzadeh, H. and Haghmorad, D. and Tabasi, N. and Rastin, M. and Khazaee, M. and Mahmoudi, M. (2015) Inhibitory effect of Crocus sativus L. ethanol extract on adjuvant-induced arthritis. Food and Agricultural Immunology, 26 (2). pp. 170-180.

[img] Text

Download (368kB)
Official URL:


Saffron is a well-known spice produced from dried stigmas of Crocus sativus L. flowers. Apart from its wide use in food preparations, it also has a broad range of medical properties. We examined the potential anti-inflammatory effects of saffron ethanolic extract (SEE) using an animal model of arthritis. Adjuvant-induced arthritis was induced in Wistar rats by injection of Complete Freund's Adjuvant. The rats were then injected intraperitoneally every other day with 25–600 mg SEE/kg or dexamethasone (DEX, 2 mg/kg). Changes in body weight, paw oedema and arthritis indices were recorded over the subsequent 12 days of treatment. Results revealed that SEE particularly at the higher concentrations significantly reduced paw and tibiotarsal joint diameters and comparing with DEX caused no significant change in body weight. These observations suggest that SEE displays a considerable anti-inflammatory potency and could potentially be used as an anti-arthritic agent in control of inflammation in rheumatoid arthritis. © 2014 Taylor & Francis.

Item Type: Article
Additional Information: Cited By :7 Export Date: 16 February 2020 CODEN: FAIME Correspondence Address: Mahmoudi, M.; Immunology Research Center, Bu-Ali Research Institute, Mashhad University of Medical SciencesIran
Uncontrolled Keywords: adjuvant-induced arthritis Crocus sativusL saffron ethanol extract Wistar rat Animalia Crocus Crocus sativus Rattus Rattus norvegicus
Subjects: WE Musculoskeletal system
QV pharmacology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib5 lib5
Date Deposited: 26 Apr 2020 07:46
Last Modified: 26 Apr 2020 07:46

Actions (login required)

View Item View Item