Knee osteoarthritis injection choices: Platelet-rich plasma (PRP) versus hyaluronic acid (A one-year randomized clinical trial)

Raeissadat, S. A. and Rayegani, S. M. and Hassanabadi, H. and Fathi, M. and Ghorbani, E. and Babaee, M. and Azma, K. (2015) Knee osteoarthritis injection choices: Platelet-rich plasma (PRP) versus hyaluronic acid (A one-year randomized clinical trial). Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders, 8.

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Introduction: Knee osteoarthritis (OA) is the most common articular disease. Different methods are used to alleviate the symptoms of patients with knee OA, including analgesics, physical therapy, exercise prescription, and intra-articular injections (glucocorticoids, hyaluronic acid HA, etc). New studies have focused on modern therapeutic methods that stimulate cartilage healing process and improve the damage, including the use of platelet-rich plasma (PRP) as a complex of growth factors. Due to the high incidence of OA and its consequences, we decided to study the long-term effect of intra-articular injection of PRP and HA on clinical outcome and quality of life of patients with knee OA. Method: This non-placebo-controlled randomized clinical trial involved 160 patients affected by knee OA, grade 1-4 of Kellgren-Lawrence scale. In the PRP group (n = 87), two intra-articular injections at 4-week interval were applied, and in the HA group (n = 73), three doses of intra-articular injection at 1-week interval were applied. All patients were prospectively evaluated before and at 12 months after the treatment by Western Ontario and McMaster Universities Arthritis Index (WOMAC) and SF-36 questionnaires. The results were analyzed using SPSS 16.1 software (RCT code: IRCT2014012113442N5). Results: At the 12-month follow-up, WOMAC pain score and bodily pain significantly improved in both groups; however, better results were deter-mined in the PRP group compared to the HA group (P< 0.001). Other WOMAC and SF-36 parameters improved only in the PRP group. More improvement (but not statistically significant) was achieved in patients with grade 2 OA in both the groups. Conclusion: This study suggests that PRP injection is more efficacious than HA injection in reducing symptoms and improving quality of life and is a therapeutic option in select patients with knee OA who have not responded to conventional treatment. © the authors.

Item Type: Article
Additional Information: Cited By :112 Export Date: 16 February 2020 Correspondence Address: Ghorbani, E.; Physical Medicine and Rehabilitation Department, Shahid Beheshti University of Medical SciencesIran; email:
Uncontrolled Keywords: Hyaluronic acid Intra-articular injection Knee osteoarthritis Platelet-rich plasma adult aged Article controlled study drug efficacy female follow up human major clinical study male McMaster Universities Arthritis Index pain assessment prospective study quality of life questionnaire randomized controlled trial scoring system Short Form 36 thrombocyte rich plasma treatment outcome
Subjects: W General medicine- Health professions
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib5 lib5
Date Deposited: 25 Apr 2020 06:57
Last Modified: 25 Apr 2020 06:57

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