Evaluation of BCL6 and MUM1 expression in patients with diffuse large B cell lymphoma and their correlations with staging and prognosis in Iran

Rahimi, H. and Jafarian, A. and Samadi, A. and Meamar, B. and Rahmani, S. (2015) Evaluation of BCL6 and MUM1 expression in patients with diffuse large B cell lymphoma and their correlations with staging and prognosis in Iran. Asian Pacific Journal of Cancer Prevention, 16 (1). pp. 83-86.

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Abstract

Background: Diffuse large B-cell lymphoma (DLBCL) is the most common form of non-Hodgkins lymphoma (NHL), accounting for approximately 25 of NHL cases. The aim of this study was to evaluate the association between the BCL6 and MUM1 gene expression and patient prognosis and stage. Materials and Methods: After ethical approval, in a cross-sectional study, tissue samples of 80 patients with diffuse large B-cell lymphoma were analyzed for BCL6 and MUM1 gene expression. Immunohistochemical staining was performed with division into categories of 0-5, 5-25, 26-50, 51-75 and more than 75. Other clinical and histological information such as lymph node involvement, T-stage, B symptoms and patient outcome were also recorded. Data were analyzed with SPSS version 16 and a P-value less than 0.05 was considered significant. Results: The patient mean age was 46.9±10.5 years (47.6±10.7 and 46.1±9.6 for males and females, respectively). A significant association was seen between lymphoma stage and BCL6 (p=0.045) but not MUM1 expression (p=0.09). However, the latter was associated with mortality (p=0.006) as was also the BCL6 level (p=0.006). Conclusions:: Overexpression of MUM1 and BCL6 is associated with poor prognosis in patients with diffuse large B-cell lymphoma.

Item Type: Article
Additional Information: Cited By :1 Export Date: 16 February 2020 Correspondence Address: Samadi, A.; Internal Medicine Research Center for Patient Safety, Mashhad University of Medical ScienceIran
Uncontrolled Keywords: BCL6 Diffuse large B-cell lymphoma Iran MUM1 Prognosis BCL6 protein, human DNA binding protein interferon regulatory factor interferon regulatory factor-4 transcription factor zinc finger protein biosynthesis cancer staging cross-sectional study female gene expression genetics human large cell lymphoma male middle aged mortality pathology Cross-Sectional Studies DNA-Binding Proteins Humans Interferon Regulatory Factors Lymphoma, Large B-Cell, Diffuse Neoplasm Staging Transcription Factors Zinc Fingers
Subjects: QZ pathology-neoplasms-Genetics
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib5 lib5
Date Deposited: 25 Apr 2020 08:01
Last Modified: 25 Apr 2020 08:01
URI: http://eprints.mums.ac.ir/id/eprint/16528

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