Malondialdehyde-Modified LDL IgG Antibody Levels and Indices of Cardiac Function in Valvular Heart and Coronary Artery Disease Patients

Rahsepar, A. A. and Mirzaee, A. and Moodi, F. and Moohebati, M. and Tavallaie, S. and Khorashadizadeh, F. and Mottahedi, B. and Esfehanizadeh, J. and Azari, A. and Khojasteh, R. and Mousavi, S. and Paydar, R. and Amini, M. and Ghayour-Mobarhan, M. and Ferns, G. A. and Sahebkar, A. (2015) Malondialdehyde-Modified LDL IgG Antibody Levels and Indices of Cardiac Function in Valvular Heart and Coronary Artery Disease Patients. Medical Principles and Practice, 24 (5). pp. 424-431.

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Abstract

Objective: To compare the changes in anti-malondialdehyde-modified low-density lipoprotein (MDA-LDL) IgG levels among patients undergoing off-pump and on-pump coronary artery bypass grafting (CABG) or valvuloplasty. Subjects and Methods: A total of 38, 39 and 34 patients who underwent off-pump CABG, on-pump CABG and valvuloplasty, respectively, were enrolled in this study. Serum anti-MDA-LDL IgG values were measured 24 h before and after the operative procedures and at discharge. Echocardiography was also done before surgery and before discharge. The results were compared with values from 50 healthy controls. Results: In all patients, a reduction in antibody titers was observed post-operatively. However, the decrease was significant only in the off-pump CABG - before surgery: 42.33 (25.83-58.51), after surgery: 30.86 (16.36-51.33) and at discharge: 10.96 (6.82-23.57; p = 0.027). There was a significant positive association between anti-MDA-LDL IgG levels and ejection fraction (r = 0.248, p = 0.036) and a negative association with E/E', a marker of pulmonary capillary wedge pressure, in the coronary patients (r = -0.345, p = 0.012), but no significant associations were found in patients with valvular heart disease. Conclusions: Serum anti-MDA-LDL IgG levels were associated with cardiac function indices in coronary patients undergoing CABG. © 2015 S. Karger AG, Basel.

Item Type: Article
Additional Information: Cited By :2 Export Date: 16 February 2020 CODEN: MPPRE
Uncontrolled Keywords: Anti-malondialdehyde-modified low-density lipoprotein Cardiac function Coronary artery bypass grafting Valvular heart disease glucose high density lipoprotein cholesterol immunoglobulin G antibody low density lipoprotein malondialdehyde modified low density lipoprotein immunoglobulin G antibody triacylglycerol unclassified drug autoantibody biological marker immunoglobulin G malonaldehyde malondialdehyde-low density lipoprotein, human adult antibody blood level antibody titer Article cardiac patient cardiovascular risk clinical article controlled study coronary artery bypass graft coronary artery disease diastolic blood pressure echocardiography female glucose blood level heart ejection fraction heart function hip circumference human male off pump coronary surgery on pump coronary artery bypass graft pulmonary artery occlusion pressure systolic blood pressure triacylglycerol blood level valvuloplasty waist circumference aged analogs and derivatives annuloplasty heart output heart surgery Heart Valve Diseases immunology middle aged procedures Autoantibodies Biomarkers Cardiac Output Cardiac Surgical Procedures Cardiac Valve Annuloplasty Coronary Artery Bypass Humans Lipoproteins, LDL Malondialdehyde
Subjects: WG Cardiovascular System
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib5 lib5
Date Deposited: 26 Apr 2020 04:03
Last Modified: 26 Apr 2020 04:03
URI: http://eprints.mums.ac.ir/id/eprint/16551

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