Trial evaluation of bone marrow derived mesenchymal stem cells (MSCs) transplantation in revival of spermatogenesis in testicular torsion

Sabbaghi, M. A. and Bahrami, A. R. and Feizzade, B. and Kalantar, S. M. and Matin, M. M. and Kalantari, M. and Aflatoonian, A. and Saeinasab, M. (2012) Trial evaluation of bone marrow derived mesenchymal stem cells (MSCs) transplantation in revival of spermatogenesis in testicular torsion. Middle East Fertility Society Journal, 17 (4). pp. 243-249.

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Defective spermatogenesis due to the failure in germ cell proliferation and differentiation is the major sign of male infertility pathogenesis; and male factor is involved in up to half of all infertile couples. Testicular torsion is an acute vascular event causing the rotation of the vascular pedicle of the testis, thereby impeding the blood flow to the testis and the scrotal contents. Azoospermia caused by torsion in testis is a common source of impotency, which has not been touched by this approach, yet. Here, we use the capacity of mesenchymal stem cells (MSCs), as multipotent adult stem cells, to revive spermatogenesis in torsion-induced azoospermia. For this purpose, MSCs were extracted from rat bone marrow, cultured and transplanted into torsioned testis. Germ cell specific markers (Oct4, Vasa and c-Kit) were monitored for the differentiation of MSCs after transplantation into the torsion azoospermed testis. This study is a trial evaluation of mesenchymal stem cells in rat torsion testis to follow up the regenerative capacity of stem cells in spermatogenesis revival. These approaches can provide the powerful tools to investigate the basic biology of stem cells for reproductive engineering and infertility treatment. © 2012 Middle East Fertility Society. Production and hosting by Elsevier B.V. All rights reserved.

Item Type: Article
Additional Information: Cited By :14 Export Date: 16 February 2020 CODEN: MEFJF Correspondence Address: Bahrami, A.R.; Department of Biology, Faculty of Sciences, Ferdowsi University of Mashhad, Mashhad, Iran; email:
Uncontrolled Keywords: c-Kit Mesenchymal stem cells (MSCs) Oct4 Testicular torsion Trial experiment Vasa biological marker octamer transcription factor 4 stem cell factor receptor unclassified drug Vasa protein animal experiment animal model animal tissue article azoospermia cell differentiation cell growth controlled study immunohistochemistry male mesenchymal stem cell transplantation nonhuman protein expression rat spermatogenesis testis torsion
Subjects: WJ Urogenital System
QU Biochemistry
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib5 lib5
Date Deposited: 25 Apr 2020 09:19
Last Modified: 25 Apr 2020 09:19

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