Saffron as an antidote or a protective agent against natural or chemical toxicities

Razavi, B. M. and Hosseinzadeh, H. (2015) Saffron as an antidote or a protective agent against natural or chemical toxicities. DARU, Journal of Pharmaceutical Sciences, 23 (1).

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Saffron (Crocus sativus) is an extensively used food additive for its color and taste. Since ancient times this plant has been introduced as a marvelous medicine throughout the world. The wide spectrum of saffron pharmacological activities is related to its major constituents including crocin, crocetin and safranal. Based on several studies, saffron and its active ingredients have been used as an antioxidant, antiinflammatory and antinociceptive, antidepressant, antitussive, anticonvulsant, memory enhancer, hypotensive and anticancer. According to the literatures, saffron has remarkable therapeutic effects. The protective effects of saffron and its main constituents in different tissues including brain, heart, liver, kidney and lung have been reported against some toxic materials either natural or chemical toxins in animal studies. In this review article, we have summarized different in vitro and animal studies in scientific databases which investigate the antidotal and protective effects of saffron and its major components against natural toxins and chemical-induced toxicities. Due to the lake of human studies, further investigations are required to ascertain the efficacy of saffron as an antidote or a protective agent in human intoxication. © 2015 Razavi and Hosseinzadeh; licensee BioMed Central.

Item Type: Article
Additional Information: Cited By :39 Export Date: 16 February 2020 CODEN: DJTSF Correspondence Address: Hosseinzadeh, H.; Pharmaceutical Research Center, Department of Pharmacodynamy and Toxicology, Mashhad University of Medical SciencesIran; email:
Uncontrolled Keywords: Antidote Chemical toxin Crocetin Crocin Crocus sativus L Natural toxin Protective Saffron Safranal 3 nitropropionic acid acrylamide aflatoxin aflatoxin B1 aluminum antibiotic agent beryllium carbon tetrachloride Crocus sativus extract cyclophosphamide dimpylate doxorubicin hexachlorobutadiene isoprenaline lipopolysaccharide paracetamol paraquat protective agent snake venom unclassified drug plant extract anticonvulsant activity antidepressant activity antihypertensive activity antiinflammatory activity antineoplastic activity antinociception antioxidant activity Article Crocus sativus embryotoxicity heart protection in vitro study liver protection liver toxicity nephrotoxicity neuroprotection nonhuman renal protection therapy effect animal chemistry Crocus human Animals Antidotes Humans In Vitro Techniques Plant Extracts Protective Agents
Subjects: QV pharmacology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib5 lib5
Date Deposited: 21 Apr 2020 05:20
Last Modified: 21 Apr 2020 05:20

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