Human papillomavirus in oral leukoplakia, verrucous carcinoma, squamous cell carcinoma, and normal mucous membrane

Saghravanian, N. and Ghazi, N. and Meshkat, Z. and Mohtasham, N. (2015) Human papillomavirus in oral leukoplakia, verrucous carcinoma, squamous cell carcinoma, and normal mucous membrane. Oman Medical Journal, 30 (6). pp. 455-460.

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Abstract

Objectives: Squamous cell carcinoma (SCC) is the most common oral malignancy, and verrucous carcinoma (VC) is a less invasive type of SCC. Leukoplakia (LP) is the most frequent premalignant lesion in the oral cavity. The human papillomavirus (HPV) has been recognized as one of the etiologic factors of these conditions. The association of anogenital and cervical cancers with HPV particularly its high-risk subtypes (HPV HR) has been demonstrated. The purpose of our study was to investigate the hypothetical association between HPV and the mentioned oral cavity lesions. Methods: One hundred and seventy-three samples (114 SCCs, 21 VCs, 20 LPs) and 18 normal mucosa samples (as a control group) were retrieved from the Department of Oral and Maxillofacial Pathology of Mashhad Dental School, Iran. The association of HPV genotypes in LP, VC, and SCC was compared to normal oral mucosa using the polymerase chain reaction. Results: The results showed the absence of HPV in normal mucosa and LP lesions. In three samples of VC (14.3), we observed the presence of HPV HR (types 16 and 18). All VCs were present in the mandibular ridge of females aged over 65 years old. No statistically significant correlation between HPV and VC was observed (p=0.230). Additionally, 15 (13.1) SCCs showed HPV positivity, but this was not significant (p=0.830). The prevalence of SCC was higher on the tongue with the dominant presence of less carcinogenic species of HPV (types 6 and 11). A statistically significant association was not observed between HPV and SCC or VC in the oral cavity. Conclusions: More studies are necessary to better understand the relationship between HPV and malignant/premalignant oral cavity lesions. © 2015, Oman Medical Specialty Board. All rights reserved.

Item Type: Article
Additional Information: Cited By :6 Export Date: 16 February 2020 Correspondence Address: Mohtasham, N.; Oral and Maxillofacial Diseases Research Center, Mashhad University of Medical SciencesIran
Uncontrolled Keywords: Carcinoma Leukoplakia Oral Squamous cell Verrucous adult age aged Article cancer tissue case control study controlled study female gender genotype human human tissue major clinical study male polymerase chain reaction retrospective study squamous cell carcinoma verrucous carcinoma Wart virus
Subjects: WC Communicable Diseases
QZ pathology-neoplasms-Genetics
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib5 lib5
Date Deposited: 22 Apr 2020 06:00
Last Modified: 22 Apr 2020 06:00
URI: http://eprints.mums.ac.ir/id/eprint/16571

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