Effect of curcuminoids on oxidative stress: A systematic review and meta-analysis of randomized controlled trials

Sahebkar, A. and Serban, M. C. and Ursoniu, S. and Banach, M. (2015) Effect of curcuminoids on oxidative stress: A systematic review and meta-analysis of randomized controlled trials. Journal of Functional Foods, 18. pp. 898-909.

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The aim of the meta-analysis was to evaluate the efficacy of purified curcuminoids supplementation on plasma activities of superoxide dismutase (SOD), catalase and glutathione (GSH) and lipid peroxides as parameters of oxidative stress. Seven randomized controlled trials were finally selected for the meta-analysis. There was a significant increase of serum SOD activities after curcuminoids supplementation (weighted mean difference WMD: 1.15 U/mL, 95% confidence interval CI: 0.49-1.82, p = 0.0007). In a subgroup analysis, no significant effects was observed in the subset of studies administering curcuminoids for <6 weeks (WMD: 0.75 U/mL, 95%CI: -0.56-2.05, p = 0.26), but a significant increase of SOD activities was found with supplementation duration ≥6 weeks (WMD: 1.46 U/mL, 95%CI: 0.60-2.32, p = 0.0009). The curcuminoids significantly reduced serum lipid peroxides (WMD: -6.35 nmol/mL, 95%CI: -11.06 to -1.64, p = 0.008), increased GSH concentrations (WMD: 5.39 μg/mL, 95%CI: 1.17-9.60, p = 0.01), and catalase activity (WMD: 51.78 U/mL, 95%CI: 15.71-87.85, p = 0.005). This meta-analysis showed a significant effect of curcuminoids in elevating serum SOD and catalase activities, GSH concentrations, and reduction of serum lipid peroxides. © 2015 Elsevier Ltd.

Item Type: Article
Additional Information: Cited By :76 Export Date: 16 February 2020 Correspondence Address: Banach, M.; Department of Hypertension, WAM University Hospital in Lodz, Medical University of Lodz, Zeromskiego 113, Poland
Uncontrolled Keywords: Curcuma longa Curcumin supplementation Curcuminoids Oxidative stress SOD Superoxide dismutase
Subjects: QV pharmacology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib5 lib5
Date Deposited: 22 Apr 2020 07:32
Last Modified: 22 Apr 2020 07:32
URI: http://eprints.mums.ac.ir/id/eprint/16575

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